Assessment of Phytochemical and Antiulcer activity of Curcuma longa leaves

Authors

  • Sandhya Sujane NRI Institute of Pharmaceutical Sciences, Bhopal, India
  • Neha Shukla NRI Institute of Pharmaceutical Sciences, Bhopal, India
  • Neeru Shukla NRI Institute of Pharmaceutical Sciences, Bhopal, India
  • Mithun Bhowmick NRI Institute of Pharmaceutical Sciences, Bhopal, India
  • Jagdish Rathi NRI Institute of Pharmaceutical Sciences, Bhopal, India

DOI:

https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(2).2949-2953

Keywords:

Peptic ulcer, Curcuma longa, leaves, methanolic extract

Abstract

Peptic ulcer is one of the world's major gastro-intestinal disorders, embracing both gastric and duodenal ulcers, and affecting 10%of the world population. a common disorder of the GIT system, which causes much discomfort to patients, disrupting their daily routines and causes mental agony. Here, present study was carried out to investigate antiulcer activity of methanol extract of Curcuma Longa leaves (family Zingiberaceae) in pylorus ligated. The result of whole study has been concluded that methanolic extract of curcuma longa leaves had two formulations which are 20 mg/kg and 50 mg/kg both are effective against paracetamol induced ulcers. The evaluation of ulcer index was conformed the effectiveness of ulcer protective and healing property of methanolic extract of curcuma longa.

Downloads

Download data is not yet available.

References

Sabiha S, Mohd AA, Asif M, Akhtar M. Role of phenolic compounds in peptic ulcer: An overview. J Pharm Bioallied Sci2011; 3:361-7.

Jainu M, Devi CS. Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: Possible mechanism for the inhibition of acid formation. J Ethnopharmacol2006; 104:156-63.

Bighetti AE, Antonio MA, Kohn LK, Rehder VL, Foglio M, Possenti A, et al. Anti-ulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip. Phytomedicine 2005; 12:72-7.

OdeO.J. and AryaO.V. VS. Indian Medicinal Plants. 1st ed. Vol. 4. Hyderabad: Orient Longman Ltd. Publication; 1995.

Bighetti AE, Antonio MA, Kohn LK, Rehder VL, Foglio M, Possenti A, et al. Anti-ulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip. Phytomedicine2005; 12:72-7. 5.

Lee, C. J., Lee, J. H., Seok, J. H., Hur, G. M., Park, Y. C., Seol, I. C. and Kim, Y. H., Effects of baicalein, berberine, curcumin and hespiridin on mucin release from airway goblet cells. Planta Med., 2003, 69, 523-52.

Sinha, M., Mukherjee, B. P., Mukherjee, B., Sikdar, S. and Dasgupta, S. R., Study of the mechanism of action of curcumin; an antiulcer agent. Indian J. Pharmacol., 1975, 7, 98.

Prasad, D.N., Gupta B., Srivastava, R.K. and Satyavati, G.V., Studies on ulcerogenic activity of curcumin. Indian J. Physiol. Pharmacol., 1976; 20: 92.

Gupta, B., Kulshrestha, V. K., Srivastava, R. K. and Prasad, D. N., Mechanisms of curcumin induced gastric ulcer in rats. Indian J. Med. Res., 1980, 71, 806-814.

Dasgupta, S. R., Sinha, M., Sahana, C. C. and Mukherjee, B. P., A study of the effect of an extract of Curcuma longa Linn. on experimental gastric ulcers in animals. Indian J. Pharmacol., 1969, 1, 49- 54.

Ghongane BB, Rahul K. Evaluation of anti-ulcer activity of Curcuma longa in rats. Journal of Advances in Pharmacy and Healthcare Research 2011; 1(2)

Ranajit K. Banerjee, CURRENT SCIENCE, VOL. 87, NO. 1, 10 JULY 2004; 44

Dashputre et al. / Evaluation of Anti-Ulcer Activity of Methanolic Extract of Abutilon indicum Linn. IJPSDR April-June 2011, Vol 3, Issue 2 (97-100) [35;1]

Rambir Singh., Ramesh Chandra., Mridula Bose., Prathibha Mehta Luthra. (2002) Current Science, 83(6): 737740.

Published

2018-04-15

How to Cite

Sujane, S. ., Shukla, N. ., Shukla, N., Bhowmick, M. ., & Rathi, J. . (2018). Assessment of Phytochemical and Antiulcer activity of Curcuma longa leaves. International Journal of Research and Development in Pharmacy & Life Sciences, 7(2), 2949 - 2953. https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(2).2949-2953

Most read articles by the same author(s)