Abstract
Sustained drug delivery means not only prolonged duration of drug delivery but also implies predictability and reproducibility of drug release kinetics. In the present study gastroretentive dosage form (tablet) was selected as a method to design sustained release dosage forms because it is a rapidly expanding technology. The objective of the work was to design sustained release tablets of Captopril as gastroretentive drug delivery dosage form of a drug meant for management of treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by diabetes, and to improve survival after a heart attack. Formulation of gastroretentive drug delivery dosage forms are done based on optimization under factorial design of formula and classed formulation batches in which concentration of polymer HPMC of various grades (HPMC K15 M, HPMC K100M and HPMC K4M) varied with the ration of sodium bi carbonate and microcrystalline cellulose. Therefore, the Aim of the present work is design to formulate and evaluate gastroretentive dosage form (tablets) of Captopril for efficient sustained release after oral administration in case of congestive heart failure, kidney problems caused by diabetes.
References
Shukla S., Patidar A., Agrawal S., Choukse R. A Review On: Recent Advancement of Stomach Specific Floating Drug Delivery System”, International Journal of Pharmaceutical & Biological Archives 2011; 2(6): 1561-1568.
Grabowski SR. “Principles of anatomy and physiology”, 10th ed. New York: John Willey and Sons; 2002.
Ostwal PP., Shrikhande VN., Mahajan NM., Jadhav YL, Jain MS., Jain SP., “A Review - Bilayer Floating Drug Delivery System”, American Journal of Pharm Tech Research. 2012; 2(3).
Haan PD, Lerk CF. “Drug delivery systems: an approach to oral controlled drug delivery via gastric retention 1984.”
Vyas SP., Khar RK, “Controlled drug delivery: Concepts and Advances”,1 ed, Vallabh Prakashan, New Delhi, 2002;15-16.
Chien YW, “Rate controlled drug delivery system: controlled release Vs Sustained Release, Programme”, Med Technology, 1989; (15) 21-46. [View in Pubmed]
Jacson EK. Renin and angiotensin. In: Hardman JG. Limbird LE editors. Goodman and Gilman’s the pharmacological basis of therapeutics. 10th ed. USA: McGraw-Hill: 2001; 821-2.
Dollery C. Therapeutics Drugs, Churchill Living stone, New York 1999; c38–c43.
Singh S, Mandoria N and sheikh A. Preformulation studies of captopril for novel oral drug delivery system. International Journal of Advances Pharmaceuticals and Research. 2012; 3(9): 1096-1099.
Anaizi N H, Swenson C. Instability of Captopril solution, Am. J. Hosp. Pharm. 1993;50: 486–488. [View in PubMed]
Seta Y, Kawahara Y, Nishimura K, Okada R. Design and preparation of captopril sustained release dosage forms and their biopharmaceutical properties, Int. J. Pharm. 1988; 41: 245–254.
Jaimini M., Rana AC. and Tanwar YS., “Formulation and Evaluation of Famotidine Floating Tablets”, Current drug delivery 2007; 4: 51-55. [View in PubMed]
Chaudhari V., Rathod H., Modasia M., “Formulation and evaluation of floating drug delivery system containing theophylline as a model drug”, International Journal of Pharmaceutics and life Science. 2015; 2(4): 695-703.
Sivabalan M., Punitha T., Reddy P, Jose A., Nigila G, “Formulation and Evaluation of Gastroretentive Glipizide Floating Tablets”, International Journal of Clinical Practice. 2011; 2(1): 03-05.
Punitha. K, Khadhir. S, Ravichandiran. V, Umadevi. S.K, Vaijayanthi.V, Padmapriya. S, Suresh Kumar.S, “Intragastric Floating Drug Delivery System of Ranitidine Hydrochloride: Formulation and Evaluation”, International Journal of Pharmaceutical Science. 2010; 2(4): 105-108.
Patel VF, Patel NM. “Intragastric Floating Drug Delivery System of Cefuroxime Axetil: In-vitro Evaluation”, American Association of Pharmaceutical Science. 2006; 7(1): 17-19.
Dave BS, Amin AF, Patel MM. Gastroretentive Drug Delivery System of Ranitidine Hydrochloride: Formulation and In Vitro Evaluation”, American Association of Pharmaceutical Science. 2004; 5(2): 34-42.
Arunachalam AB. Stephen C., Rajveer DU. “Design and evaluation of levofloxacin hemihydrate floating Tablets”, International Journal of Applied Biology and Pharmaceutical Technology. 2010; 1(2)2: 60–268.
Pare A, Yadav SK, Patil UK., “Formulation and Evaluation of Effervescent Floating Tablet of Amlodipine besylate”, Research Journal of Pharmacy and Technology 2008; 1(4): 526-530.
Parikh BA., Patel IC., Hugar JC., Kalakuntla DR., “Formulation and Evaluation of Floating Tablet of Atenolol: Functionality of Natural and Synthetic Polymer”, International Journal of Pharmaceutics and Cosmetology 2016; 3: 15-19.
Sreenivasa RK, Rakesh R., Dattatreya BU, Patil PS Biradar KV., “Development and evaluation of gastroretentive floating tablets of cefpodoxime proxetil”, International Journal of Research in Pharmacy and Chemistry, 2016; 2(1): 46-53.
Charyulu NR., Patil AB., Shastry CS., “Development of gastro retentive floating matrix tablets of diltiazem hydrochloride”, Nitte University Journal of Health Science. 2012; 1(1-3) 38-45.
How to cite this article
Rajput HS, Bhowmick M, Rathi V and Rathi. Design and evaluation of a Sustained Release Gastroretentive Dosage form of Captopril. Int. J. Res. Dev. Pharm. L. Sci. 2017; 6(2): 2535-2547.doi: 10.13040/IJRDPL.2278-0238.6(2).2535-2547.
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