Role of oxidative stress after routine Iron supplementation in normal and anemic women during pregnancy: Central Indian scenario

Authors

  • Ajai Kumar Department of Biochemistry, King George Medical College, Lucknow, India
  • Kalbe Jawad Department of Biochemistry, Uttar Pradesh University of Medical Science, Saifai, Etawah, India
  • Seema Singh Department of Respiratory Medicine, King George Medical College, Lucknow, India
  • Pradeep Sharma Department of Biochemistry, Uttar Pradesh University of Medical Science, Saifai, Etawah, India
  • Niranjan Singh Department of Biochemistry, Varun Arjun Medical college Banthra Shahjahanpur, India
  • Mrinal Gupta Department of Biochemistry, King George Medical College, Lucknow, India

DOI:

https://doi.org/10.21276/IJRDPL.2278-0238.2019.8(1).21-24

Keywords:

Iron deficiency, anemia, Oxidative stress, superoxide dismutase

Abstract

Iron deficiency anemia (IDA) is one of the most common nutritional disorders worldwide, affecting people of all ages in developed and developing countries. causes dimunition of various antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase. The objective of the study was to detect impact of iron supplementation in anaemic & non- anaemic pregnant subjects on oxidative stress. Patients are divided into two groups, Control groups (60 non-anemic pregnant women) & Study groups (60 anemic pregnant women). The blood sample (5 ml) was collected from different groups of subjects. In controls groups, a fall in catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase were seen while lipid peroxidase was found to have increased significantly after iron therapy. In study group, and increment in all markers except lipid peroxidase was seen and the level of lipid peroxidase was decreased following iron supplementation which was statistically significant (p<0.001). it may be concluded that iron deficiency anaemia is associated with free radical generation and peroxidation of vital body molecules which implies increased risk for pregnant women.

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Published

2019-01-15

How to Cite

Kumar, A. ., Jawad, K. ., Singh, S. ., Sharma, P. ., Singh, N. ., & Gupta, M. . (2019). Role of oxidative stress after routine Iron supplementation in normal and anemic women during pregnancy: Central Indian scenario. International Journal of Research and Development in Pharmacy & Life Sciences, 8(1), 21-24. https://doi.org/10.21276/IJRDPL.2278-0238.2019.8(1).21-24

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