Abstract
ABSTRACT: The main objective of the present study was to evolve and characterize the microspheres for colon specific target delivery of Ondansetron HCl for the treatment of Inflammatory Bowel Disease.
Methods: Ondansetron HCl loaded microspheres were devised by using emulsion solvent evaporation method. HPMC and Ethyl cellulose were used as polymers.
Results and Discussion: The preformulation compatibility studies between drug, excipients and microsphere formulations were carried out by Fourier transform infra-red spectroscopy (FTIR). The optimization of the process and formulation was done with respect to the different parameters like drug-polymer ratio, stirring speed, volume of internal phase and amount of emulsifying agent. The microspheres were filled into hard gelatin capsule shells which are sealed and coated with ethanolic solutions of ethyl cellulose and shellac. Drug release profile of microspheres was investigated in GIT pH specific media (O.1M HCl & Phosphate buffer pH 6.8). The FTIR spectra showed that no chemical interaction or changes take place during perpetration of formulations. The drug was stable in all the formulations. The process parameter modulation results showed that the production yields and particle size was decreased with increased stirring speed and increasing the volume of internal phase.
Conclusion: In-vitro drug release study of all ondansetron HCl loaded microsphere formulations OF1-OF4 show the release of drug released by non-Fickian diffusion n<0.85.
References
Lee WJ, Park HJ, Robinson JR. Bioadhesive-based dosage forms: the next generation. J Pharm Sci. 2000; 89:850-866.
Chourasia MK & Jain SK. Pharmaceutical approaches to colon targeted drug delivery systems. J. Pharm. Pharm. Sci. 2003; 6:33-66.
Mukherjee B, Mahapatra S, Guptab R, Patra B, Tiwari A, & Arora PA. Comparison between povidone-ethylcellulose and povidone-eudragit transdermal dexamethasone matrix patches based on in vitro skin permeation. Eur. J. Pharm. Biopharm., 2005;59(3):475-483.
Asghar L & Chandran S. Multiparticulate Formulation Approach to Colon Specific Drug Delivery, Current Perspectives. J. Pharm. Sci. 2006; 9(3):327-338.
Devrim B & Canefe K. Preparation and evaluation of modified release ibuprofen microspheres with acrylic polymers (eudragit) by quasi emulsion Solvent diffusion method: effect of variables. Acta Poloniae Pharmaceutica & Drug Res. 2006; 63(6):521-534.
Jelvehgari M, Siahi-Shadbad MR, Azarmi, S, Martin, GP &Nokhodchi, A. The microsponge delivery system of benzoyl peroxide: Preparation, characterization and release studies. Int. J. Pharm., 2006; 308(1-2):124-132.
Orlu M, Cevher E &Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int. J. Pharm., 2006; 318(1-2):103-117
Johnson J & Mukhtar, H. Curcumin for Chemoprevention of colon cancer. J. Pharm. Sci. 2007; 23:170-181.
Patra S, Choudhary AA, Khar RK, & Barik BB. Spectrophotometric method for ondansetron hydrochloride. Ind. J. Pharm. Sci. 2007;69(6): 840-841.
Chandra D, Kumar I, Jaiswal D, Ghosh, N, Singh H, Mishra A, Bhattacharya A, Bajpai M, & Jain D. Formulation and Evaluation of Satranidazole Microspheres for Colon Targeted Drug Delivery, J. Pharm. Res. 2009;2 (7):1230-1233.
Hagger FA, Boushey RP. Colorectal cancer epidemiology: incidence, mortality, survival and risk factors. Clin. Col. Rect. Surg. 2009; 22:191-197.
Dhawale SC, Bankar A &Patro M. Formulation and Evaluation Porous Microspheres of 5- Fluorouracil for Colon Targeting. Int. J. Pharm. Tech. Res. 2010; 2(2):1112-1118.
Philip AK & Philip B. Colon targeted drug delivery systems: A Review on primary and novel approaches. Oman Med. J. 2010; 25:70-78.
Jose S,Dhanya K, Cinu, TA &Aleykutty NA. Design and formulate multiparticulate system containing chitosan microspheres for the colon targeted delivery of ondansetron for the treatment of irritable bowel syndrome. Indian J Pharm Sci.2010; 72 (1): 58-64.
Kajale AD, Kamble RS, Giradkar, KP, Bakde BV, Channawar MA, &Chandewar AV. Colon targeted drug delivery using natural polymers. Int. J. Pharm. Res., 2010; 2:1-5.
Kumar SB, Kumar S, Anand P, Saravanakumar M, Thirumurthy B. Formulation and Evaluation of Celecoxib Microspheres by Using Ethylcelluose and Eudragit S-100 in Colon Drug Delivery. Der Pharma Chemica. 2010; 2(5), 322-328.
Philip A, & Philip B. Colon Targeted drug delivery systems: A review on primary and novel approaches, Oman Med J. 2010; 25(2):143-146.
Simi SP. Formulation and evaluation of Albendazole microcapsules for colon drug delivery system. Asi. Pac. J. trop. med. 2010; 2:374-378.
Sunitha S, Amareshwar P & Kumar S. Preparation and Characterizationof Ondansetron Hydrochloride Microspheres Using Various Cellulose Polymers, Int. J. cur. Pharm. Res. 2010;2(2):44-49.
Kumar KV, Kumar T, & Math T. Colon targeting drug delivery system. A review on recent approaches. J. Pharm. Biomed. Sci. 2011; 2:11-19.
Patel A, Patel D, Solanki, T, Bharadia PD, Pandya VM, & Modi DA. Novel approaches for colon targeted drug delivery system. IJPI's J. Pharm. Cosmetol. 2011; 1:86-87.
Kulkarni P, Mudit D, Selvam P, & Singh D. Formulation and evaluation of Indomethacin microspheres for colon drug delivery system. Int. res. J. Pharm. 2011;2(8):181-184.
Swapna A, Mohammad A, Wamorkar V &Swathimutyam P. Formulation and Evaluation of Mesalamine Microspheres for Colon Targeted Drug Delivery System. J. Pharm. Res. 2011;4(6):1670-1672.
Vajpayee A, Fartyal S, Singh A & Kumar S. Formulation and Evaluation of Colon Targeted Curcumin Microspheres Using Natural Polymers. J. Pharm. Res. & Opin.2011;4:108 - 112.
Modasiya MK, & Patel VM. Design of colon specific drug delivery using Sodium alginate and HPMC. J. Pharm.Res. 2012;5(4): 2253-2258.
Rajput S, Aggrawal P, Pathak A, Shrivasatava N, & Singh S. A Review on Microspheres: Methods of Preparation and Evaluation. W. J. Pharm. & Pharm. Sci. 2012 ;1( 1):422-438.
Ramteke H & Nath LK. Formulation, Evaluation and Optimization of Controlled Release Hydrogel Microspheres for Colon Targeted Drug Delivery. J. Pharm. Sci. & Res. 2012;4(2): 1739-1747.
Singh S, Singh A, Mahajan A, Pathak N, Upadhyay S & Pratap V. Formulation and Evaluation of Colon Targeted Drug Delivery of an Anti-Amoebic Drug. Int. j. pharma. Innov.2012;2(2): 138-152.
Sreelatha D & Kumar C. Colon Targeted Drug Delivery - A Review on Primary and Novel Approaches. J. Glob, Tren. Pharm. Sci. 2013; 4(3):1174-1183.
Kumar KGB, & Yadav NS. Design and Evaluation of a new Capsule-type Dosage form for Colon-Targeted Delivery of Etoricoxib. J. Pharma Sci. 2013;3(1):147-151.
Raj S, Shanthi, Sreedharan, R, Samraj P. Formulation and Evaluation of Coated Microspheres for Colon Targeting. J. App. Pharm. Sci. 2013; 3(4): S68-S74.
Sharma N &Harikumar SL. Formulation and Evaluation of Enteric Coated Microspheres of Ketoprofen Using Natural Polymers for Colon Drug Delivery. Int. J. Pharm. & Pharma. Sci. 2014;6(2): 886-892.
Prathap M, Gulshan MD & Rao R. Colon: Targeted Drug Delivery System - A Review. J. Pharm sci.2014; 3(5):429 - 437.
Filho TJ, Andreazza F, Sato ME & Murakami F. Development of a multiparticulate system containing enteric-release mini-tablets of omeprazole. Braz. J.Pharm. Sci. 2014; 50(3):505-511.
Dang T, Cui Y, Chen Y, Meng B, Tang B, & Bao B. Preparation and Characterization of Colon-Specific Microspheres of Diclofenac for Colorectal Cancer. Eur. J.Pharm.Sci. 2015;14(9):1541-1548.
Saxena A, &Kitawat S. Formulation, Development and Evaluation of Microspheres of Ketoprofen by Using Different Polymers. ASIO J.Pharma. & Her. Med. Res. 2015; 1(1):41-47.
Lei J, Ding Y, Feng M, & Cao Q. Preparation of oral levofloxacin colon-specific microspheres delivery: in vitro and in vivo studies. J. Pharm Biopharm, 2016;2(3): 982-988.
Rai G, Awesh K, Yadav, Narendra K, Jain & Agrawal, Eudragit-coated dextran microspheres of 5-fluorouracil for site-specific delivery to colon. J. Pharm. Science, 2016;23(1): 328-337.
Katta R, Deveswaran R, Bharath S, Basavaraj B. Development of Mesalazine Microspheres for Colon Targeting. J.Pharm. Res.2017;9(4):1-9.
Sharma RK and Midda AK. Preparation of Sustained Release Microspheres of Aceclofenac: Characterization &in-vivo studies. Int. J. Res. Dev. Pharm. L. Sci. 2017; 6(7):2862-2866.
How to cite this article:
Kumar S, Kaur R and Sharma R K.Formulation and evaluation of Microspheres for Colon targeted delivery of Ondansetron.Int. J. Res. Dev. Pharm. L. Sci. 2018; 7(5):3083-3091.doi: 10.13040/IJRDPL.2278-0238.7(5).3083-3091.
This Journal is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Copyright (c) 2020 Array