PREPARATION AND EVALUATION OF TOPICAL GEL OF NIGELLA SATIVA (KALONJI)
Keywords:
Topical Gel, Kalonji, Nigella Sativa, acne vulgaris.Abstract
The objective of this study was to check the effectiveness of Nigella Sativa against the microbial species Propronibacterium Acnes, to observe the zone of inhibition and to develop a topical formulation of Nigella Sativa for the treatment of Acne Vulgaris. The topical drug delivery system is simple, effective and very useful in treating acne. The gel was formulated using carbopol 940. Thus the gel developed was evaluated for various physico -chemical parameters like its physical appearance, pH, viscosity and homogeneity.
Downloads
References
Thiboutot, D., M., Straus, J., S.: Diseases of the sebaceous glands. In: Freedberg IM et al. editors. Dermatology in general medicine. Sixth edition. New York: the McGraw- hill com. 2003;1: 675-85.
Stathakis, V., Kilkenny, M., Marks, R. :Descriptive epidemiology of acne vulgaris in the community. Australas J Dermatol, 1997; 38:115-23.
Webster, G., F.: Inflammation in acne vulgaris. J Am Acad Dermatol, 1995; 33:247-53.
Lorraine Pena G, Gel Dosage Forms, Theory Formulation and Processing, The Upjohn Company Kalamazoo, Michigan, 381- 87.
Jyotsana Madan, Ramnik Singh, Formulation and Evaluation of Aloe Vera Topical Gels, Int. J. Ph. Sci., May-Aug, 2010; 2(2):551-555.
Charakida, A., Charakida, M., Chu, A., C.: Double-blind, randomized, placebo-controlled study of a lotion containing triethyl citrate and ethyl linoleate in the treatment of acne vulgaris. Br J Dermatol, 2007;157:569-74.
Heffernan, M., P., Nelson, M., M., Anadkat, M., J.: A pilot study of the safety and efficacy of picolinic acid gel in the treatment of acne vulgaris. Br J Dermatol, 2007; 156:548-52.
Ikram M, Hamdard Medicus, 1983; 26:16-17.
Fayyaz Ahmad, Rafeeq A. Khan, Shahid Rasheed, Study of Analgesic and Anti Inflammatory Activity FromPlant Extracts of Lactuca Scariola and Artemisia Absinthium. J. Islam. Acad. Sci, 5: 111- 114, (1992).
N. Duganath, S. Rubesh Kumar, R. Kumanan and K. N. Jayaveera, Evaluation of Anti-Denaturation Property and Anti-Oxidant Activity of Traditionally Used Medicinal Plants, International Journal Of Pharma And Bio Sciences V1(2) 2010, P.No.1-7.
Sharma Jagriti, Samagandi Kashinath, P Suresh, Evaluation of Analgesics Activity of Angamard Prashman Ghan Vati and Kakatinduk Vati WSR to its Anti Nociceptive Action, International Journal of Ayurvedic and Herbal Medicine 2:3 (2012) 510:514.
Zaoi, A., Cherrah, Y., Alaoui, K., Mahassini, N., Amarouch, H., Hassar, M.: Effects of Nigella Sativa fixed oil on blood homeostasis in rats. J Ethnopharmacol, 2002; 79:23-6.
Salem, M., L.: Immunomodulatory and therapeutic properties of the Nigella Sativa L. seeds. Int Immunopharmacol, 2005;5: 1749-70.
Toama, M., A., El-Alfy, T., S., El-Fatatry, H., M.: Antimicrobial activity of the volatile oil of Nigella Sativa Linneaus seeds. Antimicrobial Agents and Chemotherapy, 1974; 6: 225-26.
Haq, A., Abdullatif, M., Lobo, P., I., Khabar, K., S., Sheth, K., V., Al-Sedairy, S., T.: Nigella Sativa: effect on human lymphocytes and polymorphonuclear leukocyte phagocytic activity. Immunopharmacol, 1995; 30:147- 50.
Kruk, I., Michalska, T., Lichszteld, K., Klanda, A., Aboul- Enin, H., Y.: The effect of thymol and its derivatives on reactions generating reactive oxygen species. Chemosphere, 2000;41:1059-64.
Al-Ghamdi, M., S.: The anti-inflammatory, analgesic and antipyretic activity of Nigella Sativa. J of Ethnopharmacology, 2001;76:45-48.
Ait Mbarek, L., A., Mouse, H., A., Elabadi, N. et al.: Anti- tumor properties of blackseed (Nigella Sativa L.) extracts. Braz J Med Biol Res, 2007:1-8.
Clause, G.W. Understanding Microbes: A Laboratory Textbook for Microbiology; W.H. Freeman and Company: New York, USA, 1989.
http://www.pharmasm.com/pdf_files/2013012110591 3_ketan_306.pdf.
Published
How to Cite
Issue
Section
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
.