Peer Review, UGC Care
DRUG DELIVERY ACROSS HUMAN NAIL: A NEWER APPROACH
View PDF

Keywords

Transungual drug delivery system, nail plate, nails disorders, anti-fungal drugs.

How to Cite

Kumar, K. ., V. Fateh, S. Ahmad, Pant, N. C. ., & Pandey, S. . (2014). DRUG DELIVERY ACROSS HUMAN NAIL: A NEWER APPROACH. International Journal of Research and Development in Pharmacy & Life Sciences, 3(6), 1225-1230. Retrieved from https://ijrdpl.com/index.php/ijrdpl/article/view/399

Abstract

Transungual drug delivery system deals with the drug delivery through the hard keratinized nail plate. Different topical nail formulations like lacquers, enamel, and varnish are used for cosmetic purposes.They serve to protect the nail plate but also beautify and impart attractive colors. In present scientist and different researchers are working to treat different nail diseases like onycomycosis, nail psoriasis, yellow nail syndrome, paronychia. Nails disorders are mainly due to fungal infection, when drug is given through oral/systemic route, potency of drug gets decreased at the site of action. To avoid this lose of drug potency topical route of administration is used. The absorption of drugs into the nail unit to the nail plate is essential to produce therapeutic effects. By means of transungual drug delivery system oral toxicity of different drugs like anti-fungal can be avoided and also drug get longer contact time at the site of application. However nail permeability is low but this can be modified by altering the nail plate barrier by means of chemical treatments, penetration enhancers as well as physical and mechanical methods.

View PDF

References

Di Chiacchio N, Kadunc BV, De Almeida AR, Madeira CL. Nail abrasion. J.Cosmet. Dermatol. 2003; 2: 150– 152.

2. Baden HP, Gold Smith LA, Fleming B. Comparative study of the physicochemical properties of human keratinized tissues. Biochemical Biophysics ET Acta. 1973: 322, 269-78.

Hemali BG, Gerald B. Kasting. Effect of hydration on thepermeation of ketoconazole through human nail plate in vitro. Eu.J. Pharma. Sci, 2007; 32: 254–260.

Narasimha MS, Dora EW, Christopher PB. Iontophoretic drug delivery across human nail, J Pharma Sci 2007; 96(2):305-311.

Cohen PR, Scher RK, Topical and surgical treatment of onychomycosis. J. Am. Acad.Dermatol. 1994; 31: S74– S77.

Bothiraja C, Ajit K, Mukesh S, Rajalakshmi S. Nail Drug Delivery System. Indian J Pharma Edu Res 2006; 2: 264-267.

Baran, R., Amorolfine nail lacquer. A new Transungual Delivery System for nail mycoses. J. Am. Med. Assoc. Southeast Asia 1993; 9 ( 4): 5–6.

Lubeck DP. Measuring health-related quality of life in onychomycosis. J. Am. Acad. Dermatol. 1998: 38, 64– 68.

Sudaxshina M, Drug delivery to the nail following topical application, InternationalJournal of Pharmaceutics. 2002; 236: 1–26.

Debruyne D, Coquerel A. Pharmacokinetics of antifungal agents inonychomycoses. Clin. Pharmacokinet. 2001:40, 441–472.

Mertin D, Lippold BC. In vitro permeability of the human nail and of a keratin membrane from bovine hooves: prediction of the penetration rate of antimycotics through the nail plate and their efficiency. J. Pharm. Pharmacol. 1997; 49: 866–872.

Gupchup GV, Zatz JL, Structural characteristics and permeability properties of the human nail: a review. J. Cosmet. Sci. 1999; 50: 363–385.

Grover C, Bansal S, Nanda S, Reddy BS, Kumar V. Combination of surgical avulsion and topical therapy for single nail onychomycosis: a randomized controlled trial. Br. J. Dermatol. 2007; 157:364–368.

Firoz S, Naga Sirisha M, Rajalakshmi R. Transungual Drug Delivery System – A Review. Int. J. Innovative Drug Discovery 2011; 1: 9-14.

Kassan, D.G., Lynch, A.M., Stiller, M.J.,. Physical enhancement of dermatologicdrug delivery: iontophoresis and phonophoresis. J. Am. Acad. Dermatol. 1996: 34 (4), 657–666.

Repka, MA, Mididoddi, PK, Stodghill SP. Influence of human nail etching forthe assessment of topical onychomycosis therapies. Int. J. Pharm. 2004: 282, 95– 106.

Rothermel E, Apfelberg, DB. Carbon dioxide laser use for certain diseases of thetoenails. Clin. Podiatr. Med. Surg.1987: 4, 809–821.

Kasting GB, Barai ND, Wang TF, Nitsche JM. Mobility of water in humanstratum corneum. J. Pharm. Sci. 2003: 92, 2326–2340.

Quintanar-Guerrero D, Ganem-Quintanar A, Tapia- Olguin P, Kalia YN, Buri P. The effect of keratolytic agents on the permeability of three imidazole antimycoticdrugs through the human nail. Drug Dev. Ind. Pharm.1998: 24, 685–690.

Mohorcic M, Torkar A, Friedrich J, Kristl J, Murdan S. An investigation intokeratinolytic enzymes to enhance ungual drug delivery. Int. J. Pharm. 2007: 332, 196– 201.

Patel RP, Naik SA, Patel NA, Suthar AM. Drug Delivery across Human Nail. Int J Current Pharma Res 2009; 2: 1- 7.

Behl PN. Abrasion in the treatment of nail disorders. Indian J. Dermatol.1973: 18, 77–79.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

Copyright (c) 2020 Array

Downloads

Download data is not yet available.