Abstract
Prazosin is an antihypertensive drug classifiedas an adrenergic receptor antagonist, alphablocker. It’s short half-life and increased dosing frequency suggest the needfor a controlled delivery of Prazosin hydrochloride for better patient compliance.Floating drug delivery system can provide sufficient gastric retention which may help to providesustained release dosage form with enhanced absorption. Different formulation of Prazosin hydrochloride floating microspheres were successfully developed using emulsion solvent diffusion method. The microspheres had good yield and showed high, drugentrapment efficiency. The flow properties of microspheres were within the acceptable range and therefore would be easily filled into capsules. Release properties were satisfactory and the formulations hold promise for further development into drug delivery systems for oral administration of Prazosin hydrochloride.
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