Abstract
The conventional dosage forms stay in the stomach for 0.5-2 hours and passes to small intestine and where it gets absorbed within 3-6 hours. Therefore difficult to adjust release retardation and stomach retention of drug for longer period of time. The present research work was attempted to formulate and evaluate the floating tablet with biphasic release of metoprolol succinate. Metoprolol succinate bioahesive gastric drug delivery system was prepared using bioadhesive polymer PEO, Hydrophylic polymer (Carbopol 71G, HPMC E15, Methacrylic acid, Pectin, Carragenan and Guargum) and gas forming agent Sodium bicarbonate. Metoprolol succinate bioahesive gastric drug delivery system was proved to be attained the effective plasma concentration higher than the Marketed formulation. This is due to retaining metoprolol succinate in the stomach (Where it absorbed more) by means of floating and bioadhesive property of the polymer. Metoprolol succinate bioahesive gastric drug delivery system using PEO and HPMC E15 polymers could be effective sustained release formulation.
References
Narendra C, Srinath M, Ganesh B, Optimization of bilayer floating tablets containing Metoprolol tartrate as a model drug for gastric retention, AAPS Pharm Sci.Tech 2006; 7;E1-E7.
Amidon LG, Lobenberg R, kim JS, pharmacokinetics of an immediate release, a controlled Release and a two pulse dosage form in dogs. Eur.j.pharm.Bio pharm 2005; 60; 17-23.
Rekhi GS,Nellore RV, Hussain AS,Tillman LG.Development of Metoprolol tartrate extended release matrix tablet. J.Controlled release 1198;50;247-256.
Chavanpatil M, Jain P; Chaudhary S, Shar S, Vavia P, Novel sustained release swellable and bioadhesive gastro retentive drug delivery system for Ofloxacin.Int.J.Pharm.2006,316;89-92.
Qi H,Chen W, Huang C, Li L.Development of Polaxamer analogs/Carbopol based in situ gelling and Mucoadhesive ophthalmic delivery system for Puerarin.Int.J.Pharm..2007, 337;178-187.
Srivastava AK,NarayanRao D,Wadhwa R.S. and Mishra B. Oral sustained delivery of Atenolol from floating matrix tablets formulation and invitro evaluation. Drug Dev Ind Pharm 2005; 31:367-374.
Rahman Z, Ali M,Khar R. Design and evaluation of bilayer floating tablets of Captopril. Acta pharm.2006;56;49-57.
Jain KS, Agarwal GP,Jain NK.A novel Calcium silicate microsphere of Repaglinide; Invivo Investigation. J.Control release; 2006; 113; 111-116.
Baugmgartner S, Kristl J, Vrecer F,Vodopivee P, Zorko B, Optimization of floating matrix tablets and evaluation of their gastric residence time.Int.J.P.harm;2004;195;125-135.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Copyright (c) 2020 Array