TOTAL BODY CLEARANCE AND MEAN RESIDENCE TIME OF TAMOXIFEN IN FEMALE HEALTHY SUBJECTS

Authors

  • Kiran Shahbaz Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
  • Faqir Muhammad Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
  • Bilal Aslam Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
  • Kanwal Shahbaz Department of Oncology, (Center for Breast Cancer) Perfect Health Pvt. Ltd, Islamabad.
  • Ijaz Javed Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan

Keywords:

Total body clearance, mean residence time, tamoxifen body clearance, total body clearance breast cancer medicine.

Abstract

Objective: To investigate total body clearance and mean residence time after single oral dose of tamoxifen in female healthy subjects focusing on two concepts pharmenzymonetics and pharmgeonetics for the first time in Pakistan.

Methodology: Two parameters were investigated in eight healthy female subjects after single oral dose of 20mg tablet Nolvadex brand. Blood samples were collected and plasma concentration was determined by Gradient HPLC method to evaluate the total body clearance and mean resident time. Subjects were kept under observation for 4 weeks detecting any adverse signs or symptoms.

Results: Value of total body clearance mean ±SE was 39.7 ± 0.55 L/Hr/Kg and that of mean residence time MRT is 15.18 ± 0.19 Hours. There were no adverse signs reported during 4 weeks of direct observation of subjects after oral single dose. Blood pressure, temperature, pulse rate and appearant activity of subjects remained normal.

Conclusion: The total body clearance and MRT of tamoxifen is greater as compared to literature value in the healthy females of Pakistan due to pharmgeonetics.

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References

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Published

2016-05-15

How to Cite

Shahbaz, K. ., Muhammad, F. ., Aslam, . B. ., Shahbaz, K. ., & Javed, I. . (2016). TOTAL BODY CLEARANCE AND MEAN RESIDENCE TIME OF TAMOXIFEN IN FEMALE HEALTHY SUBJECTS. International Journal of Research and Development in Pharmacy & Life Sciences, 5(3), 2142-2146. Retrieved from https://ijrdpl.com/index.php/ijrdpl/article/view/230

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