Abstract
The objective of the present investigation was to study hepatoprotective activity of ethanolic extract of leaves of Anthocephalus cadamba, paracetamol induced liver damage model in rats. In this study, liver damage in rats done by paracetamol(2g/kg b.w.) in Tween 80. The ethanolic extract of the plant was administered in rats daily for seven days. The biochemical parameters were investigated. Histopathological changes in liver were studied. Silymarine was used as a standard hepatoprotective agents. The result indicates that biochemical changes produced by paracetamol were restored to normal by ethanolic extract. The ethanolic extract of leaves of Anthocephalus cadamba (ROXB.) showed significant hepatoprotective effect againest paracetamol induced liver damage model in rats.
References
Brown RT & Chapple CL; Anthocephalus alkaloids: cadamine and isocadamine. Tetrahedron Letters.19:1629-1630,1976.
Bhandarkar M & Khan A; Antihepatotoxic effect of Nymphaea stellata willd against carbon tetrachloride hepatic damage in albuno rats.Journal of Ethanopharmacol91:61-4,2004.
Banergi N; A new saponin from stem bark of anthocephalus cadamba Miq. Indian Journal of Chemical Biology 1977;15B:645.
Handa SS, Kapoor VK, International book of pharmacgnosy. New Delhi; Vallabh Prakashan 124-26,1989.
Kapil A, Koul I and Suri OP; Antihepatotoxic effects of chlorogenic acid from anthocephalus cadamba. Phytotherapy Reaserch 9(3): 189-193,1995.
Khandelwal KR; Practical pharmacognosy techniques and experiments. NIrali publication18:153-157,2007.
Lee KJ, Woo ER, Choi CY; Protective effect of acetosides on carbon tetrachloride induced hepatotoxicity. Journal of Science, 74,1051-64,2004.
Mondal S, Dash GK, Acharyya A; Analgesic, anti-inflammotory and antipyretic studies of neolamarckia cadamba barks. Journal of Pharmacy Research 1133-6,2009.
Salkar IV, Kakkar KK & Chakre; Glossary of indian medicinal plants with active principles, CSIR, New Delhi, part1, 75,1992.
Suresh SV, Sujatha C, Syamala J, Nagasudha B, Mishra SH; Protective effect of root of extract of operculina turpenthum Linn. against paracetamol induced hepatotoxicity in rats. Indian Journal of Pharmaceutical Sciences 68:32-5,2006.
Synthesis and antimicrobial activity of N-{4-[(6-chloro-4-oxo-4H-chromen-3-yl-methylene)-imino]phenyl}-2-(substituted phenoxy acetamide) derivatives, IJPSR, Vol. 2 (6), 2011, pp. 1495-1501.
Umanchigi SP, Kumar GS, Jayaveera K, Kishore KD, Ashok KC, Dhanapal R; Antimicrobial, wound healing and antioxidant activities of anthacephalus cadamba. African Journal of Traditional, Complementary and Alternative med 4:481-7, 2007.
Ullas PD, Prasanna KS, Chandrashekar KS, Antimicrobial acticity of anthocephalus cadamba Miq. Herbal heritage 3:146-7, 2009.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Copyright (c) 2020 Array