Preparation and evaluation of an Emulgel of Hydroxyzine hydrochloride


  • P.K. Lakshmi Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Hyderabad, India
  • K. Mounika Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Hyderabad, India
  • N. Kalyani Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Hyderabad, India



Emulgel; o/w emulgel; w/o emulgel; Hydroxyzine hydrochloride


Hydroxyzine hydrochloride is effective in the treatment of urticaria and other allergic skin disorders. Hydroxyzine hydrochloride emulgel potentially enhances drug penetration into the stratum corneum and localizes the drug within the dermo-epidermal layers. Emulgel was formulated by first preparing the emulsion using fixed oils and non-ionic surfactants, and then incorporated into a gel base. Emulsions were primarily optimized using non-ionic surfactants, Span 60 and Tween 20 and gel was optimized using Carbopol 940, HPMC K100M and xanthan gum. These optimized formulations were studied for in vitro drug release studies followed by ex vivo, skin irritation and stability studies. The optimized o/w emulgel was compared with the w/o emulgel which showed the in vitro release of 76.7% and ex vivo studies showed 42.3% release at the end of 8th hr. The ex vivorelease of optimized HESX (o/w emulgel) formulation was compared with the HESX1 (w/o emulgel) formulation which showed the release of 53% and 42.3% release respectively. The emulgel formulation HESX showed irritation potential of '0', thus proving to be non-irritant. Hence, it can be concluded that o/w emulgel formulation of hydroxyzine hydrochloride showed better release than the w/o emulgel.


Download data is not yet available.


Anu H, Sonali J, Sanjay J. Emulgel: an emergent tool in topical drug delivery. IJPSR. 2014;(5):1653-1654.

Vikas S, Seema S, Baibhav J, Rana AC. Emulgel: a new platform for topical drug delivery. International Journal of Pharma and biosciences. 2012;(3):485-489.

Bazigha KR, Eman FG, Sahar AF, Heyam SS, Saeed AK. Development and Evaluation of Ibuprofen Transdermal Gel Formulations. Tropical Journal of Pharmaceutical Research. August 2010;9 (4): 355-363.

Upadhyaya S, Chauhan BS, Kothiyal P. Emulgel: A Boon for Dermatological Diseases. International Journal of Pharmaceutical Research & Allied Sciences, 2014;(3):3-5.

Arpan AS, Kamal K, Rushabh S, Rajesh AK. Emulgel: A Topical Preparation for Hydrophobic Drugs. PhTechMed. Sept-Oct 2013;2(5):370-371.

Sunny K, Gurpreet S, Seema S, Gill NS. Topical drug delivery system. International Journal of Universal Pharmacy and Bio Sciences. September-October 2014;3(5):124-137.

Kute SB, Saudagar RB. Emulsified gel A Novel approach for delivery of hydrophobic drugs: An overview. JAPR. Oct-Dec 2013;3 (4):368-376.

Sonam V, Charu S, Easwari TS, Shukla VK, Emulsion Based Gel Technique: Novel Approach for Enhancing Topical Drug Delivery of Hydrophobic Drugs. IJPRS.2014;3(2):649-660.

Bhatt P, Gnanarajan G. Emulgels: A novel formulation approach for topical delivery of hydrophobic drugs. International research journal of pharmacy. 4(2),12-16.

Shelke SJ, Shinkar DM, Saudagar RB. Topical gel: a novel approach for development of topical drug delivery system. International Journal of Pharmacy & Technology. Nov-2013; 5(3): 2739-2763.

Mohammed Haneefa KP, Sherry E, Hafsa PV, Guru PM, Chandini N. Emulgel: An Advanced Review. J. Pharm. Sci. & Res.2013; 5(12): 254 – 258.

Singh RP, Parpani S, Narke R, Chavan R. Emulgel: a recent approach for topical drug delivery system. AJPR. March –April. 2014; 2 (2): 112-123.

Maria G, Dept of Chemical Engineering, LTH, Lund University. Sweden, Evaluation of different methods for characterization of physical properties of cosmetic emulsions, 1-8.

Akash MP, Viren NS, Mehul P, Nisarg NL. Formulation and Evaluation of an Emulgel Containing Silver Sulfadiazine for Topical Use. Journal of Medical and Pharmaceutical Innovation. 2014;1(6S):28-34.

Eby G, Manju MM. Formulation and evaluation of topical gel containing hair growth promoters for the treatment of androgenic alopecia. Bulletin of Pharmaceutical Research. 4(1):1-8.

Teena O, Sonali N. Formulation and Evaluation of Mefenamic acid emulgel. IJPR. 5(12):091-100.

Roman P. Stability and Characterizationof Emulsions in the presence of Colloidal Particles and Surfactants,1-204.



How to Cite

Lakshmi, P. ., Mounika, . K. ., & Kalyani, N. . (2018). Preparation and evaluation of an Emulgel of Hydroxyzine hydrochloride. International Journal of Research and Development in Pharmacy & Life Sciences, 7(2), 2962 - 2968.