Modelling of Anti-HIV-1 Activity of Piperidine-4-carboxamide CCR5 Antagonist: Role of Structural Manipulatio

Authors

  • A. K. Tiwari Department of Chemistry, Jain University, Bangalore, Karnataka, India
  • N. Agrawal Department of Chemistry, Govt. Girls P.G. College, Khandwa, India
  • M. Thakur Department of Chemistry, Symbiosis University of Applied Sciences, Indore, India
  • G. Nagendrappa Department of Chemistry, Jain University, Bangalore, Karnataka, India
  • A. Thakur Department of Applied Sciences, National Institute of Technical Teachers Training and Research, Bhopal, India

DOI:

https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(3).3006-3010

Keywords:

anti-HIV-1, Piperidine-4-Carboxamide, CCR5 antagonists, Multiple regression

Abstract

Present study is aimed to understand the role of structural manipulation in modeling of anti-HIV-1 activity of Piperidine-4-Carboxamide CCR5 antagonists. For the purpose a set of 21 Piperidine-4-Carboxamide has been chosen. Study explores the role of various, structural features like size, substitution and steric properties in anti-HIV-1 activity of Piperidine-4-Carboxamide CCR5 antagonists derivatives. Multiple regression method is adopted to understand the role of structural manipulation in modeling the logIC50 activity. Statistics generated from the study shows that none of the parameter having statistical significant value of r but bi-parametric to tetra-parametric combinations produced the improved regression value.

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How to cite this article:

Tiwari A.K., Agrawal N., Thakur M., Nagendrappa G. and Thakur A. Modelling of Anti-HIV-1 Activity of Piperidine-4-carboxamide CCR5 Antagonist: Role of Structural Manipulation. Int. J. Res. Dev. Pharm. L. Sci. 2018; 7(3): 3006-3010. doi: 10.13040/IJRDPL.2278-0238.7(3).3006-3010

This Journal is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

Published

2018-06-15

How to Cite

Tiwari, A. K. ., Agrawal, N. ., Thakur, . M. ., Nagendrappa, . G. ., & Thakur, A. . (2018). Modelling of Anti-HIV-1 Activity of Piperidine-4-carboxamide CCR5 Antagonist: Role of Structural Manipulatio. International Journal of Research and Development in Pharmacy & Life Sciences, 7(3), 3006 - 3010. https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(3).3006-3010