Design, Development and Evaluation of Extended Release Tablets of Anti-asthmatic Agents using various Polymers
DOI:
https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(4).3050-3054Keywords:
HPMC K100M, Xanthan gum, Salbutamol sulphate, Theophylline, matrix tabletsAbstract
The aim of this investigation was to define and assess Salbutamol sulphate and Theophylline framework tablets, prolonged discharge dosage form, for the treatment of Chronic Obstructive Pulmonary Disease (COPD). Powder blends of the drugs (Salbutamol sulphate and Theophylline) and polymers (HPMC K100M and Xanthan Gum) were evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose which shows satisfactory results. The direct compression method was used for the preparation of Extended-release tablets using hydroxyl propyl methyl cellulose (HPMC K100M), a semi-synthetic polymer, and xanthan gum(a natural polymer) in changing ratios keeping the total weight 250 mg for each tablet. The fabricated tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability and drug content. The results of all these tests were found to be satisfactory as per guidelines mentioned in the standards. The in-vitro dissolution study was carried out for 24 hours using type II dissolution apparatus. Among all the formulation, F7 shows 97.16 ±0.59 % of drug release at the end of 12 hours. This finding reveals that above a particular concentration of HPMC K100M and xanthan gum are capable of providing extended drug release from the dosage form.
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Rahman MM, Roy S, Hasan S, Alam AM, Ahsan QM, Ferdaus JM, Effect of mode addition of disintegrants on the dissolution of model drug from wet granulation tablets, International Journal of Pharma Sciences and Research, 2011, Volume 02, Issue 02, Pages 84-92.
Singhvi G, Singh M, Review: In vitro drug release characterization models, International Journal of Pharmaceutical Studies and Research, 2011, Volume 02, Issue 01, Pages 77-84.
Pogula M, Nazeer S, Extended-release formulation, International Journal of Pharmacy and Technology, 2010, Volume 02, Issue 04, Page 625-84.
Ghosh A, Gupta KS, Formulation development and in-vitro evaluation of sustained release matrix tablets of Salbutamol sulphate, Journal of Pharma Research and Healthcare, 2003, Volume 02, Pages 113-138.
Jayanthi B, Manna PK, Madhusudhan S, Mohanta GP, Manavalan R, Per oral extended release products- A overview, Journal of Applied Pharmaceutical Science, 2011, Volume 01, Issue 02, Pages 50-55.
El-halim AMS, Amin MM, Gazayerly ENO, Gawad EAN, Salbutamol sulphate controlled-release hydrophilic matrix tablets, RGUHS Journal of Pharmaceutical Sciences, 2011, Volume 01, Issue 03, Pages 194-200.
Sharma PP, Sharma S, Khokra LS, Sahu KR, Jangde R, Singh J, Formulation, development and evaluation of sustained release matrix tablets containing Salbutamol sulphate, Pharmacologyonline 2, 2011, Pages 1197-1203.
Ahsan QMd, RahmanMMd, Jha MK, Ahmed I, Lachman L, Lieberman AH, Kanig LJ, Tablets, "The Theory and Practice of Industrial Pharmacy", 1990, Volume 03, Pages 293-345.
Mizanur Md, Mogha R,Rahman MdH, Development and in-vitro evaluation of sustained release matrix tablets of Salbutamol sulphate using Methocel K100M CR polymer, International Journal of Pharmaceutical Sciences and Research, 2011, Volume 02, Pages 567-576.
Guneri T, Arci M, Ertan G, Preparation and diffusional evaluation of sustained release suppositories containing Ibuprofen microspheres, Fabad Journal of Pharma Sciences, 2004, Volume 29, Pages 177-84.
Pudnec ME, Schwartz DJ, Oral solid dosage form, "In Remington: The science and practice of pharmacy", London: Lippincott and Williams and Wilkins, 2002, Issue 20, Pages 858-93.
Cooper J, Gunn C, "Tutorial pharmacy", New Delhi, CBS Publishers and Distributors, 1986, Issue 06, Pages 211-33.
Kondahiah A, Prakash K, Design of controlled release non-erodible polymeric matrix tablets of Theophylline using a sintered technique, Indian Journal of Pharmaceutical Sciences, 2002, Volume 64, Issue 03, Pages 239-43.
Ibric S, Jovanovic M, Djuric Z, Parojcic J, Petrovic SD, Soloman L, Satupar B, Artificial neural networks in the modelling and optimization of Aspirin extended-release tablets with eudragit L 100 as matrix substance, AAPS Pharm Sci Tech, 2003, Volume 04, Issue 01, Pages 1-9.
Satturwar PM, Fulzelle SV, Mondaogade PM, Dharwhekar GN, Dorle AK, Rosin derivatives as hydrophobic matrix materials for controlled release of Diclofenac sodium, Indian Journal of Pharmaceutical Sciences, 2001, Volume 64, Issue 02, Pages 138-41.
Wu PC, Tsai MJ, Huang YB, Cheng JS, Tsai YS, In-vitro and in-vivo evaluation of Potassium chloride sustained release formulations prepared with saturated polyglycolide glycerides matrices, International Journal of Pharmaceutics, 2002, Issue 243, Pages 119-24.
Sumati R, Lalla JK, Poddar SS, Formulation and evaluation of controlled release Aspirin tablets, Indian Journal of Pharmaceutical Sciences, 2001, Volume 63, Issue 02, Pages 110-13.
Reza MS, Quadir MA, Haidher SS, Development of Theophylline sustained release dosage form based on kollidone SR, Pakistan Journal of Pharmaceutical Sciences, 2002, Volume 15, Issue 01, Pages 63-70.
Verma RK, Kaushal AM, Garg S, Development and evaluation of extended-release formulations of Isosorbide mononitrate based on osmotic technology, International Journal of Pharmaceutics, 2003, Issue 263, Pages 9-24.
Qiu Y, Flood K, Marsh K, Caroll S, Trivedi J, Arneric SP, Krill SL, Design of sustained-release matrix systems for a highly water-soluble compound, ABT-089, International Journal of Pharmaceutics, 2003, Issue 157, Pages 43-52.
Dashora K, Saraf S, Effect of processing variables on the microparticulate system of Nimesulide, The Chinese Pharmaceutical Journal, 2006, Issue 58, Pages 67-74.
Yeole PG, Galgette UG, Babla IB, Nakhat PD, Design and evaluation of xanthan gum based sustained release matrix tablets of Diclofenac sodium, Indian Journal of Pharmaceutical Sciences, 2006, Volume 01, Pages 185-89.
Basak SC, Reddy BMJ, Mani KPL, Formulation and release behaviour of sustained release Ambroxol hydrochloride HPMC matrix tablets, Indian Journal of Pharmaceutical Sciences, 2006, Volume 01, Pages 594-98.
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