Analytical method development and validation for Aluminium

Authors

  • Chandrashekhar Bhagvatrao Helaskar Bombay college of Pharmacy, Sundarnagar, Kalina, Santacruz east Mumbai, India
  • S.R. Kulkarni Bombay college of Pharmacy, Sundarnagar, Kalina, Santacruz east Mumbai, India

DOI:

https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(4).3034-3038

Keywords:

Colorimetric method, 8-hydroxyquinoline-5-sulphonic acid, ICH guidelines Aluminium

Abstract

Aluminium comprises about 8% of earth's crust so there is possibility that aluminium can contaminate the natural resources, with references to previous researches on determination of aluminium, we developed a simple, rapid, and economic colorimetric method for the detection of aluminium from various sources. Aluminium has an electric charge and a small ionic radius of about 0.51Å, conferring upon it strong polarizing capabilities. Standard reduction potential for reacting Al+3 is -1.67 V. This high electronegativity makes aluminium highly reactive. 8-hydroxyquinoline-5-sulphonic acid has been used for chelation and subsequent determination of aluminium content from samples. It is a light-yellow coloured compound and is a derivative of heterocyclic quinoline substituted with the hydroxyl group on carbon number 8 and sulphonic acid group at carbon number 5. Sulfonic acid improves the solubility of the molecule and of the corresponding fluorescent complexes in polar solvents. Aluminium readily complexes with 8-hydroxyquinoline-5-sulphonic acid in acidic buffer and remains stable for 30 mins. The maximum absorbance of aluminium and 8-hydroxyquinoline-5-sulphonic acid complex was determined using UV spectro-photometry at 359 nm. Concentration of aluminium in the sample was found to be linear within the range of 1.2-2.8 mM with acceptable precision and accuracy, as per guidelines. The developed method was validated according to ICH (Q2R1) guidelines. The developed method was used to assess the aluminium content in a marketed antacid formulation. The recovered aluminium content was within the industrial acceptance limit. The developed method is thus effective for accurate determination of aluminium from marketed samples.

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References

Organization, W. H., Aluminium in drinking-water: Background document for development of WHO guidelines for drinking-water quality. 2003

Ogimoto, M.; Suzuki, K.; Haneishi, N.; Kikuchi, Y.; Takanashi, M.; Tomioka, N.; Uematsu, Y.; Monma, K., Aluminium content of foods originating from aluminium-containing food additives. Food Additives & Contaminants: Part B 2016,9 (3), 185-190.

Bache, B., Aluminium mobilization in soils and waters. Journal of the Geological Society 1986,143 (4), 699-706.

Reinke, C. M.; Breitkreutz, J.; Leuenberger, H., Aluminium in over-the-counter drugs. Drug Safety 2003,26 (14), 1011-1025.

Kawahara, M.; Muramoto, K.; Kobayashi, K.; Mori, H.; Kuroda, Y., Aluminium Promotes the Aggregation of Alzheimer? s Amyloid β-Protein in Vitro. Biochemical and biophysical research communications 1994,198 (2), 531-535.

Ogawa, M.; Kayama, F., A study of the association between urinary aluminium concentration and pre-clinical findings among aluminium-handling and non-handling workers. Journal of Occupational Medicine and Toxicology 2015,10 (1), 13.

Zanjanchi, M.; Noei, H.; Moghimi, M., Rapid determination of aluminum by UV-vis diffuse reflectance spectroscopy with application of suitable adsorbents. Talanta2006,70 (5), 933-939.

Zanjanchi, M.; Noei, H.; Moghimi, M., Rapid determination of aluminium by UV-vis diffuse reflectance spectroscopy with application of suitable adsorbents. Talanta2006,70 (5), 933-939.

Kefala, G.; Economou, A.; Sofoniou, M., Determination of trace aluminium by adsorptive stripping voltammetry on a preplated bismuth-film electrode in the presence of cupferron. Talanta2006,68 (3), 1013-1019.

Hejri, O.; Bzorgzadeh, E.; Soleimani, M.; Mazaheri, R., Determination of trace aluminium with eriochrome cyanineafter cloud point extraction. World Applied Sciences Journals 2011,15, 218-222.

Memon, N.; Bhanger, M., Micellar liquid chromatographic determination of aluminium as its complex with 8-hydroxyquinoline-5-sulfonic acid. Acta Chromatographica2004,14, 172-179.

Lian, H.; Huang, Q.; Kang, Y.; Zou, G.; Bi, S.; Tian, L. C., Extraction with Toluene and HPLC Determination of Aluminium in the Form of an 8?Hydroxyquinoline Derivative. Journal of liquid chromatography & related technologies 2003,26 (2), 273-283.

Guideline, I.H.T.,Validation of analytical procedure; text and methodology, Q2 (R1), 2005. 1.

Huber, L., Validation of analytical methods. Agilent Technologies. Germany 2010.

Published

2018-08-15

How to Cite

Helaskar, C. B. ., & Kulkarni, S. . (2018). Analytical method development and validation for Aluminium. International Journal of Research and Development in Pharmacy & Life Sciences, 7(4), 3034 - 3038. https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(4).3034-3038