Abstract
ABSTRACT: Objective: In view of the present study, the object of the study was to formulate and evaluate nasal in situ gel contains Ondansetron hydrochloride. Methodology: Ondansetron hydrochloride loaded colloidal dispersion were prepared for nasal drug delivery using various polymers like carbopol (0.4%) and HPMC (1%) concentrations. The optimized formulation contains benzalkonium chloride as a preservative, sodium chloride as a tonicity adjuster, 0.5 M NaOH to maintain pH. The finished formulation was characterized for its clarity, pH, viscosity, drug content, net content, weight loss on storage, in vitro diffusion and in vitro bioadhesive strength. Result: Ondansetron hydrochloride was successfully formulated as a pH induced in situ gel for nasal administration and have potential to avoid first pass effect than oral route. Conclusion: The results of the study conclusively proved the suitability a nasal in situ gel of Ondansetron hydrochloride which was developed and formulated in this study is ideal for nasal administration for the treatment of antiemetic
References
Basu. S, Bandyopadhyay A.K. Review article on Nasal drug delivery; Int J Pharm 2010; 4(1): 125-127.
Chien, Y.W. Textbook of Novel drug delivery system, second edition. Marcel Dekker, New York. 2005, 229
Talegaonkar, S., Mishra, P.R. Intranasal delivery: An approach to bypass the blood brain barrier. Indian J Pharmacol 2004; 36: 140-7.
Behl CR, Pimplaskar HK, Sileno AP et al., Optimization of systemic nasal drug delivery with pharmaceutical excipients. Adv. Drug Delivery Rev. 1998; 29: 117-133.
Ibrahim A.A., Amel Y. H., Fars K. A., Gamal M.M; Vesicular drug delivery system for nasal; 2009, SPB- 28319
Arora, P., Sharma S., Garg, S. Permeability issue in nasal drug delivery. Drug Delivery. Tech. 2002; 7(18): 967-974.
Chhajed Sachin, Sangale Sagar and Barhate S.D. Advantageous nasal drug delivery system: A Review; IJPSR 2011; 2(6): 1322-1336.
Dhakar R.C, Maurya S.D, Kumar T.V, Gupta A.K, Girija D, A review on factor affecting the design of nasal drug delivery system. IRJP 2010; 1(1): 29-42.
Chug Y, Kapoor P, Kapoor A.K., Intranasal drug delivery: a novel approach. Indian J. Otolaryngol. Head Neck Surg. 2009; 61: 90-94.
Critchley H, Davis SS, Farraj NF, Illum L. Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system. J. Pharm. Pharmacol. 1994; (46): 651-6.
Alpar HO, Bowen JC, Brown MRW., Effectiveness of liposomes as adjuvants of orally and nasally administered tetanus toxoid. Int. J. Pharm. 1992; 88: 335-344.
How to cite this article:
Danao KR, Gangane PS, Mahajan NM and Mahajan UN. Formation and Development of Ondansetron Hydrochloride Nasal in situ gel. Int. J. Res. Dev. Pharm. L. Sci. 2018; 7(5): 3100-3103. doi: 10.13040/IJRDPL.2278-0238.7(5).3100-3103
This Journal is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Copyright (c) 2020 Array