DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE IN SYNTHETIC MIXTURE
Keywords:
Dapagliflozin, Metformin hydrochloride, Antidiabetic, Spectrophotometric analysis, Simultaneous equation method.Abstract
The objective of the work is to develop UV spectroscopic method for simultaneous estimation of Dapagliflozin (DAPA) and Metformin hydrochloride (MET). This method involve solving of simultaneous equations based on measurement of absorbance at two wavelengths 225 nm and 237 nm. Both the drugs obey the Beer’s law in the concentration ranges employed for this method. Results of the methods were validated statistically. Novel, simple, sensitive, rapid, accurate and economical spectrophotometric methods have been developed for simultaneous estimation of Dapagliflozin and Metformin hydrochloride. The method can be used to estimate the amount of Dapagliflozin and Metformin hydrochloride in mixture containing Dapagliflozin and Metformin hydrochloride.
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References
Dapagliflozin, http://www.drugbank.ca/drugs/DB062 92 [cited on 2014 15th Sept].
Metformin hydrochloride, http://www.drugbank.ca/drugs/DB00331 [cited on 2014 15th Sept] .
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