FORMULATION AND CHARACTERIZATION OF FAST DISSOLVING TABLET OF THIABENDAZOLE

Abstract

Thiabendazole is an anthelmintic drug inhibits the enzyme fumarate reductase and thus provide cidal action to the helminth. Thiabendazole have low bioavailability about 30 to 40%. The main aim of the present investigation was to increase the bioavailability of the drug an d to provide the cidal action against the helminth by preparing fast dissolving tablet. Thiabendazole is effective in helminthic infection in children and fast dissolving tablets are most suitable for the children due to ease of administration and no water requirement. Fast Dissolving Tablet of Thiabendazole provide rapid onset of action with better release. Fast dissolving tablets of Thiabendazole was prepared by Direct compression method and evaluated by pre-compression and post-compression parameter. Benzimidazole derivatives are less soluble in water and for fast dissolving tablets the water solubility is prime requirement and that can be achieved by using Acrysol K-150 Polymer. Among all the formulation the tablet ODT6 that contains Co-proceed super disintegrants Kyron T-314 with maximum amount of microcrystalline cellulose and Acrysol K-150 was considered to be best formulation and which release upto 98.75% within 3 Minutes.The tablet that contains combination of sodium starch glycolate and croscarmellose sodium (ODT8) is found as second best tablet and Provide 97.78% Drug release.