Abstract
The title compound (CDC II), C28H28N6O3, is a potential impurity found in commercial product candesartan cilexetil, consist of N- ethylation of tetrazole moiety attached to biphenyl ring, selectively at N-6 position. The Crystal structure held together by C-H×××O intermolecular interactions. Crystal structure of the title compound was obtained by single crystal X-ray diffraction which was crystallizes in the monoclinic space group P21/n with cell parameter a = 12.1574(12)Å, b = 13.9178(14)Å,c = 15.9742(19)Å and Z = 4.
References
World Health Organization, 1211 Geneva 27, Switzerland, www.who.int/en
S. Ahuja, Impurities evaluation in pharmaceuticals, Marcel Deckker, NY, 1998
ICH guideline, Impurities in new drug substances Q3A (R1) dated 7 February 2002
U.S. Department of Health and Human Services Food and Drug Administration, Guidance for Industry, ANDAs: Impurities in Drug Substances, January 2005.
Committee for proprietary medicinal products, Guideline on control of impurities in pharmaceutical substance, Apr 2004.
Raman B, Sharma B , Mahale G, Singh D, Kumar A (2011) Journal of Pharmaceutical and Biomedical Analysis 56:256-263
S.C. Sweetman (Ed.), Martindale – The Complete Drug Reference, 36th ed., Pharmaceutical Press, London, 2009, 1238–1239
Etinger MY, Hildesheim VN, Fedotev B, Dolitzky B, WO Patent 2005//111021 A1.
H. Stenhoff, P. Lagerstrom, C. Andersen, (1999) Journal of Chromatography B 731: 411–417
N. Ferreiros, S. Dresen, R.M. Alonso, W. Weinmann, J. Chromatography B 855 (2007) 134–13
J. Havlicek, Z. Mandelova, R. Weisemann , I. Strelec, L. Placek, S. Radl , Collct. Czech. Chem. Commun. 74 (2009) 347–362.
Oxford Diffraction (2009). CrysAlis CCD and CrysAlisPro RED, Version 1.171.33.34d. Oxford Diffraction Ltd., Abingdon, Oxfordshire, England
Sheldrick, G. M. (2008) Acta Cryst. A64, 112-122
Spek, A. L. (2003) J. Appl. Crystallogr. 36, 7-13
Farrugia, L. J. (1999) J. Appl. Cryst. 32, 837-8
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Copyright (c) 2020 Array