ANTIPSORIATIC ACTIVITY OF DITHRANOL TRANSDERMAL PRONIOSOMES GEL ON SWISS ALBINO MICE

Abstract

Psoriasis is distinguished by hyper-proliferation and unusual differentiation of epidermal keratinocytes, lymphocyte infilteration containing mainly of T lymphocytes. Psoriasis may be treated mainly by topical and dermal route because systemic therapy or phototherapy mainly concerns with the possible tissues toxicity and sometimes result in carcinogenicity. Beyond the various presently existing management options of psoriasis, topical therapy is the most widely used. Proniosomes create beneficial choice for transfer of the drug without delay. Simultaneously, its provided better physical and chemical stability than comparison to liposomes and niosomes. Proniosomes is converted to niosomes prior to action and release of drug. Proniosomal transdermal gel of Dithranol optimized preparation was used for antipsoriatic activity on Swiss albino mice give relevant result for treatment of psoriasis, without any tissue toxicity such as redness, erythema in animal skin, as well as convulsion, tremor, circling, depression, hypothermia and mortality. Percent drug activity of Proniosomal transdermal gel (1% w/w) was found to be 79.56% which show a significant antipsoriatic effect in comparison of standard drug Derobin® (1.125w/w) 82.31%. The frequently shown different side effects associated with dithranol, in this research solved related problem of existing preparation of dithranol by using of proniosomes transdermal gel preparation on animal body as tissue toxicity study.