Abstract
FK 506 is an immunosuppressive agent and highly stable 11-amino acid cyclic polypeptide. Present study demonstrated that FK 506 at the dose and time periods (1 mg / kg over 7 or 28 days impair the rat tissue based organic constituents, FK 506 depleted the rat tissue total protein, carbohydrate, lipid and glycogen contents of all rat tissues selected for the present study and whereas the same FK 506 treatment enhanced the rat tissues FAA and FFA contents: compared to saline treated rat control tissues. The overall data it is evident that FK 506 administration in the present study impairs the overall general metabolism of rat tissues.
References
Bierrer B.E. (1995) Proc Assoc Am Phys.107:28-40.
Kelly PA, Burckart GJ, Venkataramanan R. (1995) Am J Health Syst Pharm. 52:1521-35.
Isoniemi H, Tikkanen M., Hayry P, Eklund, B., Hockerstedt, K., Salmela, K. and Ahonen J.(1991). J. Transplant. Proc. 23(1):1029-1031.
Lowry OH, Rosenbrough JJ, Farr AL, Randall RJ. (1951) J. Biol. Cehm., 193:265-275.
Carrol NV, Longley RW, Row JH (1956). J.Bio.Chem. 22:583-593.
Folch J, Lees M, Sloane-Stanley GH (1957) J Biol Chem. 226:497-509.
Christie WW. (1982) Permagon Press Canada Ltd.,Toronto, Ont .
Moore S, Stein WH. (1954) In: Methods in enzymology. (eds.), Colowick and Kaplan, Vol.II, Academic Press. New York. P.501.
Schmidt Ullrich R, Wallach DFH, Ferber E. (1974). Biochem. Biophys. Acta. 356 : 288-299.
Bergmeyer HV. (1974). Lipase methods in enzymatic analysis. Academic Press Inc., New York, San Francisco, London. 819.
Letko E, Ahmed AR, Foster CS. (2001) Graefes Arch Clin Exp Ophthalmol. 239 (6): 441– 444.
Inamura T, Yamamoto S, Ohgane J, Hattori N, Tanaka S, Shiota K. (2004) Biochem Biophys Res Comm. 322: 593–600.
Kawashima H, Fujino Y, Mochizuki M. Antigen-specific suppressor cells induced by FK 506 in experimental autoimmune uveoretinitis in the rat. Invest Ophthalmol Vis Sci. 1990; 31:31–38.
Kahan BD, Chang JY, Seghal SN. (1991) Transplantation. 52:185–191.
Rajeswara Rao M, Sivaprasad K, Ramana Rao KV. (1983) Proc. Ind. Natn., Sci. Acad. B49(5): 416-420.
Begley DJ. (1992) Progress in Brain Research. 91: 163- 169.
Carrol PB, Goncalves AA, Boschero AC, Tzakis AG, Starzl TE, Atwater I. (1991). J. of Transplant. Proc. 23(1):337-339.
Imai K, Sata K, Nakayama Y, Takishima T, Osakabe T, Yokata K, Yamagishi K, Uchida H, Uchida H, Hiki Y, Kakita A. (1991). Transplant. Proc. 23(1): 1589-1592.
Pipelleers D, Pipelers Marichal M, Markholst H, Hoorens A, Kloppel G. (1991). Diabetologia. 34(6):390-396.
Neto AB, Haapalainen E, Ferreira R, Feo CF, Misiako EP, Vennarecci G, Porcu A, Dib S A, Goldenberg S, Gomes PO, Nigro AT. (1999) Transplant International. 12(3): 208-212.
Mohammad AH, Hai Ayobe M, Beskharoun MA, El Damaramy NA. (1972) Toxicon. 10:139-149.
Bhatia SC,Venkatasubramanian TA. (1972) J. Agr. Food Chem. 20:993-996.
Teraoka S, Kawai T, Yamaguchi Y, Tojinbara T, Fujita S, Nakajima I, Nkagawa Y, Fujikawa H, Hayashi T, Honda H, Fuchinoue S, Agishi T, Ota K. (1989). Transplant. Proc., 21(1): 2774-2779.
Kay JE, Moore AL, Doe SEA, Benzie CR, Schonbrunner R, Schmid FX, Halestrap AP. (1990) J. Transplant. Proc.22 (1): 96-99.
Dehpour AR, Nouhnejad P, Mousavizadeh K, Ghafourifar P, Djamali M, Borhanimoghadam B. (1996). Toxicology. 108: 65-71.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Copyright (c) 2020 Array