Abstract
Taste masking becomes a pre-requisite for bitter drugs to improve the patient compliance especially in the pediatric and geriatric population. Metoclopramide hydrochloride is recommended in dose of 10 to 15 mg four times a day for getting relief from nausea, vomiting, stomach pain and reflux oesophagitis. It finds application in all the categories of patients.In the present study an attempt has been made to prepare bitterless fast dissolving tablet of Metoclopramide Hydrochloride using stevia leaf powder as a taste masking agent. Direct compression was the technique used for preparing taste masked tablets.
References
Biradar SS, Bhagavati ST, Kuppasad IJ., The Int. J. Pharmacol;4(2): 2006, 1531-2976.
Kaushik D, Dureja H, Saini TR., Indian Drugs-Bombay; 41:2004, 187-93.
Seager H., J Pharm Pharmacol; 50: 1998, 375-8.
. Chue P, Welch R, Binder C. “Acceptability and disintegration rates of orally disintegrating risperidone tablets in patients with schizophrenia or schizoaffective disorders”, Can J Psychiatry.,2004; 49:701Y703.
Shu T, Suzuki H, Hironaka K, Ito K. “Studies of rapidly disintegrating tablets in oral cavity using coground mixture of mannitol with crospovidone”, Chem Pharm Bull (Tokyo)., 2002; 50:193Y198.
British pharmacopoeia, “Metoclopramide Hydrochloride”
vol II, 3921‐3923, 2009.
Silvers D, Kipnes M, Broadstone V, et al. Clinical therapeutics 20 (3): 1998, 438–53.
Dahima Rashmi, Sharma Rajesh,et al.Formulation and evaluation of taste masked orodispersible tablet of metoclopramide HCL usiog indion 204”,Int.J.of ChemTech Research., 2010;2(1):447-453.
Gohel M, Patel M, Amin A, Agrawal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolve tablets of Nimesulide using vacuum drying technique. AAPS PharmSciTech 2004; 5: article 36.
Vora N, Rana V. Pharm Dev Tech. 2008, 13(3), 233- 243
Shaikh SA, Shaikh SS, Thota RS, Shahi SR, Shookur SA, Pakhare AN. Formulation and development of s-(-)- Amlodipine besylate tablets to improve the dissolution profile. A J P 2007; 1(1): 124-8.
Khan S, Kataria P, Nakhat P, Yeole P. Taste masking of Ondansetron hydrochloride by polymer carrier system and formulation of rapid- disintegrating tablets. AAPS pharmscitech 2007; 8 (2) article 46:e1-7.
Nishii, Hiroyuki, Kobayashi, Hirohisa, Otoda, Kazuya. Tablets Quickly Disintegrated in The Oral Cavity.European Patent EP1153616.

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