Abstract
The aim of this study was to investigate the efficacy and side effects of domperidone in childhood gastroesophageal reflux disease. This outcome study was done on 220 children (1month -15years) referred with reflux-related gastrointestinal and extra gastrointestinal symptoms during 3 years. Upper endoscopy with biopsy was performed in all subjects except in infants with apnea. Trial therapy was begun with domperidone (0.6mg/kg/BID) 30 minutes before meal. The efficacy and side effects were evaluated in 4-week follow up. Those free of symptom were considered as positive therapeutic response. In children with esophagitis, omeprazol was prescribed for 3 months too. Follow up continued monthly for three months and then every 3-6 months up to 2 years. Mean age of subjects was ±3.5 years. There was no significant different between two sex(female=55%, male=45%).There was poor correlation between clinical symptoms with endoscopic and histologic findings (100%, 66.4%, 82.7%). Majority of the patients (85.5%) responded to the treatment in 4 weeks. There was no significant relationship between age, sex and clinical symptoms with response to domperidone. Although side effects were observed in 22.4%, but the most frequent side effect (15%) was loose stool .Moreover this complication (constipation) was beneficial in relieving simultaneous reflux related constipation. Serious complications such as extrapyramidal signs were observed only in 0.5%. According to this study, domperidone with few side effects can be efficient for the treatment of reflux in children with any gastrointestinal or extra- gastrointestinal symptom regardless of the sex or age group, moreover further study for finding out rare complications is suggested too.
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