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ANALYSIS OF CYTOTOXIC POTENTIAL OF THE AQUEOUS LEAF EXTRACTS OF POGOSTEMON AURICULARIUS (L.) HASSK. USING ALLIUM CEPA ROOT TIP ASSAY
Vol. 2 No. 5 (2013), Research
Vol. 2 No. 5 (2013)

ANALYSIS OF CYTOTOXIC POTENTIAL OF THE AQUEOUS LEAF EXTRACTS OF POGOSTEMON AURICULARIUS (L.) HASSK. USING ALLIUM CEPA ROOT TIP ASSAY

Research
Published 2013-09-15
Anjana S.
Cell and Molecular Biology Division, Department of Botany, University of Calicut, Kerala-673635, India
John E. Thoppil
Cell and Molecular Biology Division, Department of Botany, University of Calicut, Kerala-673635, India
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Keywords

Pogostemon auricularius, cytotoxicity, Allium cepa assay, aberrations, mitotic index.

How to Cite

Anjana S., & Thoppil, J. E. . (2013). ANALYSIS OF CYTOTOXIC POTENTIAL OF THE AQUEOUS LEAF EXTRACTS OF POGOSTEMON AURICULARIUS (L.) HASSK. USING ALLIUM CEPA ROOT TIP ASSAY. International Journal of Research and Development in Pharmacy & Life Sciences, 2(5), 562-566. Retrieved from https://ijrdpl.com/index.php/ijrdpl/article/view/308
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Abstract

Pogostemon auricularius is an aromatic herb belonging to the family Lamiaceae.

Objectives: In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and antimitotic potential of P. auricularius.

Methods: The roots of Allium cepa were exposed to different concentrations of the aqueous leaf extracts (0.01%, 0.05%, 0.1% and 0.5%), for four different time durations, using distilled water as the control. 

Results: Chromosome anomalies including formation of sticky chromosomes, chromosome bridges and several other metaphasic and anaphasic disorders were induced by all the extract concentrations.

Conclusions: Mitotic index was found to be decreasing, which was concentration dependent. All the extracts induced lowering of the mitotic index when compared to the distilled water control.

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