Abstract
ABSTRACTObjectives: HBV vaccination leads to both humoral and cellular immune response and can be evaluated using HBs- specific antibodies.
Methods: Cross-sectional study was carried out at tertiary care hospital. A total 120 HBV vaccine compliant HCW were evaluated for quantitative anti-HBs by enzyme immune assay.
Results: 110 (91.7%) subjects had protective levels of anti-HBs. Higher age at vaccination was an important risk factor in low vaccine response. Doctors had higher levels of anti-HBs titres when compared to laboratory technicians and staff nurse.
Conclusion: We recommend that all HCWs should undergo ‘initial anti-HBs’ assay within one to three months (less than six months) of last dose of primary vaccination .HCW having initial anti-HBs titers of less than 10 mIU/ml should be investigated for HBV infection and if negative, they should be offer second HBV vaccination series.
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