Abstract
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels (arteries, capillaries and veins). It is the most serious disease on which extensive research is being done all over the world. Structure based drug designing offers a computational approach to identify the potential leads which can be developed into a drug. The In-Silico study of the current work aimed at inhibiting target MAPK P38 protein. This exhibited a minimal energy against the targets hence suggesting the stability of the compound. Five different forms of apigenin were docked against target, stated that all five is efficient to act on the targets by exhibiting promising interactions and good scores. Especially pure form of apigenin shows very efficient score than others. Since it is from a natural source the compound is nontoxic and has reduced side effects.
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