Abstract
To compare S. Creatinine & estimated GFR the glomerular filtration rate (GFR) by using Cockcroft-Gault (CG) and Modification of Diet in Renal Diseases (MDRD) formula in diabetics and hypertensive is the best overall index of renal function in health and disease. Insulin clearance is the gold standard but since it is time consuming and is invasive technique it is poorly specified.
The study was conducted retrospectively reviewed individuals in a hospital on A total number of 320 cases from dec 2013 to dec 2014 in them 120 cases of type II DM, 120 cases of hypertensives and 100 cases of both type II DM and hypertensive patients of age group between 20-70Years who had a Macrovascular complication chronic kidney disease, according to their stages of CKD, as stages I,II,III,IV,V. THE Serum Creatinine was calculated and compared with Cockcrost-Gault and MDRD approaching Annai Medical college & hospital, Pennalur, Sriperumbadur, Chennai.
GFR Estimation (e GFR): MDRD study Equation (GFR ml/min/1.073m2 r GFR = 186 × (S Cr) -1.154 × (age)-0.203 × (0.742 if female) × (1.210 if African American) Cockcrost-Gault (CG ml/min0 = (140-age) × weight /0.85 (if females)/ (SCr Mean ±SD of S. Creatinine, MDRD and cock craft & Gault S.Creatinine increased and eGFR is decreased in stages III, IV,V of CKD when Compared to stages I , II. CKD is taking under stages comparing with eGFR ,MDRD equation and Cockcroft-Gault formula .see the statistical data eGFR is high the serum creatinine is decreased ,s.creatinene increased eGFR is decreased but statically significance in s.creatinine is the p 0.01 ,MDRD p value <0.001 and Cockcroft-Gault p ≤0.05. This shows us that MDRD p <0.001 is highly significant than S.Creatinine and Cock craft & Gault.
MDRD study is most significant than Cock graft & gaults S- Creatinine in predicting the risk and for instituting appropriate therapy to reduce the incidence of the chronic kidney disease e GFR is better predictor
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