Abstract
The anti-hyperlipidemic effect of Polyherbal formulation (PHF) was tested in Triton and fat diet induced hyperlipidemic rat models. Here, Acute hyperlipidemia was induced by administration of single dose of Triton X 100 (400 mg/kg,i.p) and Chronic hyperlipidemia was induced by feeding fat diet for 21 days to rats. Treatment with Polyherbal formulation (PHF) (200 and 400 mg/kg, p.o ) significantly reduced the hyperlipidemia i.e., decreased levels of serum Total Cholesterol, Triglycerides, Low Density Lipoprotein Cholesterol (LDL-C), Very Low Density Lipoprotein Cholesterol (VLDL-C) , an increase of serum High Density Lipoprotein Cholesterol (HDL-C) when compared to vehicle control and standard drug Atorvastatin (10 mg/kg). The results demonstrated that Polyherbal formulation (PHF) possessed significant antihyperlipidemic activity.
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