PREPARATION OF OCULAR IN SITU GEL FOR GLAUCOMA TREATMENT USING ISOLATED FORSKOLIN FROM COLEUS FORSKOLII ROOT

Authors

  • Shiva Kumar Yellanki Department of Pharmacy, Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh, India.
  • Balaji Anna Department of Pharmaceutics, Trinity College of Pharmaceutical Sciences, Peddapalli- 505172, Karimnagar, Telangana, India.
  • Marupaka Radha Kishan Department of Pharmaceutics, Govt. Polytechnic for Women, Hanamkonda- 506009, Warangal, Telangana, India.

Keywords:

Two-level factorial design, Forskolin, In vivo intra ocular pressure reduction, In Vitro gelation time.

Abstract

The loss of drug eye environment by various routes is overcome by formulating the viscous formulations. The aim of this ingestion was to optimize and anti glaucoma activity evaluation of in situ gel containing extracted forskolin. Various polymers are used and investigated the effect and optimized the formulation on the bases of In Vitro gelation and in vitro drug release. Temperature, pH and ion activated polymers are used to optimize the formulations and were evaluated for drug content, clarity, and gelling capacity. In vivo intra ocular pressure (IOP) reduction studies and results observed in acceptable range. Based on gelation time (sec) and in vitro percentage drug release P8 formulation was found to be best optimized formulation from the developed by 23 factorial design. This study revealing that the forskolin effectively reduced the glaucoma in rabbits.

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Published

2015-01-15

How to Cite

Yellanki, S. K. ., Anna, B. ., & Kishan, M. R. . (2015). PREPARATION OF OCULAR IN SITU GEL FOR GLAUCOMA TREATMENT USING ISOLATED FORSKOLIN FROM COLEUS FORSKOLII ROOT. International Journal of Research and Development in Pharmacy & Life Sciences, 5(1), 1981-1985. Retrieved from https://ijrdpl.com/index.php/ijrdpl/article/view/210

Issue

Vol. 5 No. 1 (2015): Volume 5 Issue 1, December - January (2015)

Section

Research
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