FORMULATION DEVELOPMENT AND EVALUATION OF MATRIX TYPE LIDOCAINE TOPICAL PATCH FOR LOCAL ANESTHETIC

Authors

  • Nimesh Goswami Department of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India
  • Paresh Prajapati Department of Pharmaceutics, K. J. College of Pharmacy, Gujarat University, Vdasma, Mehsana, India

Keywords:

Topical patch, Lidocaine, Release liner, Non-Woven backing film, penetration enhancers, matrix stiffener.

Abstract

Objective: The objective of the present study was to develop a more patient, elegant, stable, good adhesion and convenient dosage form, namely drug in the adhesive topical patch containing Lidocaine as a local anesthetic.

Material and method: For preparation of a topical patch of Lidocaine with the help of penetration enhancer which gives good adhesion and maintained up to 12 hours delivery. Topical patch to adhere for 12 hours with help of different adhesive and select adhesive based on delivery of Lidocaine. Compatible excipients with Lidocaine and polymer were selected for stability of formulation. Other excipients were also added for stabilizing the blend and final topical patch. After finalization of the formulation, evaluate the formulation as per the evaluation parameter of topical patch. Final formulation is also tested for identifying the delivery of Lidocaine from the patch, also charged for three months stability to know the self-life of the formulation.

Results: Formulated patch had been evaluated for weight variation, thickness, moisture content, drug content, degradation product, adhesion study, dissolution study and in-vitro diffusion study. Three month stability study of the final formulation was carried out and results of stability study were found satisfactory showing the stability of the formulated topical patch.

Conclusion: Based on evaluation of topical Lidocaine patch, it was concluded that final formulation of Lidocaine is adhered and deliver in 12 hours and stable for 3 month in accelerated condition.

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Published

2015-01-15

How to Cite

Goswami, N. ., & Prajapati, . P. . (2015). FORMULATION DEVELOPMENT AND EVALUATION OF MATRIX TYPE LIDOCAINE TOPICAL PATCH FOR LOCAL ANESTHETIC. International Journal of Research and Development in Pharmacy & Life Sciences, 5(1), 1963-1973. Retrieved from https://ijrdpl.com/index.php/ijrdpl/article/view/208