Abstract
Fentanyl is an opioid general anaesthetic acting through the opioid receptors. Combination with local anaesthetics increases the onset and duration of analgesia. The present study compared the efficacy profile of epidurally administered bupivacaine alone and fentanyl combined with bupivacaine.
A total of 30 adult patients of either sex aged 20-50 years, undergoing lower abdominal elective surgery under epidural anesthesia were included in the present study. Patients were randomly divided into two groups of 15 each. Bupivacaine (0.5%) 20 ml was administered for both the groups epidurally and 100μg fentanyl was given to the second group. The onset and duration of sensory analgesia were observed and compared. Postoperative visual analgesic scale scores were also noted and compared. Data was analyzed using unpaired “t” test.
The demographic profile of patients was comparable in two groups. Onset of analgesia was earliest in second group compared to the first group. The duration of analgesia was also significantly prolonged in second group. There was no significance difference in the VAS scores between two groups throughout the study period.
Fentanyl and bupivacaine group has early onset of analgesia as well as produced prolonged duration. Hence, the combination of fentanyl and bupivacaine may useful in feature clinical settings.
References
Bromage PR. The price of intraspinal narcotic analgesics: Basic constraints (editorial). Anaesth Analg 1989; 68:323-7.
Moore RA, Bullingham RE, McQuay HJ, Hand CW, Aspel JB, Allen MC, et al. Dural permeability to narcotics: In vitro determination and application to extradural administration. Br J Anaesth 1982; 54:1117-28.
Fujinaga M, Mazze RI, Baden JM, Fantel AG, Shepard TH. Rat whole embryo culture: An in vitro model for testing nitrous oxide teratogenicity. Anesthesiology 1988; 69:401-4.
Malik P, Manchanda C, Malhotra N. Comparative evaluation of epidural fentanyl and butorphanol for post-operative analgesia. J Anesthesiol Clin Pharmacol 2006; 22:377-82.
Szabova A, Sadhasivam S, Wang Y, Nick TG, Goldschneider K. Comparison of postoperative analgesia with epidural butorphanol/bupivacaine versus fentanyl/bupivacaine following pediatric urological procedures. J Opioid Manag 2010; 6:401-7.
Gustafsson LL, Schildt B, Jacobsen K. Adverse effects of extradural and intrathecal opiates: Report of a nationwide survey in Sweden. Br J Anaesth 1982; 54:479-86.
Camporesi EM, Nielsen CH, Bromage PR, Durant PA. Ventilatory CO2 sensitivity after intravenous and epidural morphine in volunteers. Anesth Analg 1983; 62:633-40.
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