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METABOLOMICS: CURRENT TECHNOLOGIES AND FUTURE TRENDS
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Keywords

Metabolome, metabolite, metabolomics.

How to Cite

Kasture, V. S. ., Musmade, D. S. ., Vakte, M. B., Sonawane, . S. B. ., & Patil, . P. P. . (2013). METABOLOMICS: CURRENT TECHNOLOGIES AND FUTURE TRENDS. International Journal of Research and Development in Pharmacy & Life Sciences, 2(1), 206-217. https://doi.org/10.21276/ijrdpl.v2i1.169

Abstract

The emerging field of metabolomics had profound importance in recent years as its wide applications in the field of drug discovery and drug development. With recent advances in the field of metabolomics it can be proved as a major tool in the process of drug discovery and development. In the agricultural/chemical industry, metabolomics may be used to develop herbicides and pesticides With increasing importance being placed on health and safety related aspects of our food, metabolomics can potentially be a valuable tool to monitor and improve the quality of what we eat; for example, in food processing and quality control, or in plant breeding for improved crop varieties and in the development of novel foodstuffs. The present review reveals the importance of metabolomics in drug discovery along with recent advances in the techniques of metabolomics along with its wide applications in various fields like drug discovery, drug toxicity profiling, food industries especially in food and allied beverages testing.

https://doi.org/10.21276/ijrdpl.v2i1.169
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References

Teresa W.-M. Fan, Pawel Lorkiewicz, Katherine Sellers , Hunter N.B. Moseley , Richard M. Higashi, Andrew N. Lane, Stable isotope-resolved metabolomics and applications for drug development, Pharmacology & Therapeutics 2011; 6, 112-123.

Ute Roessner and Jairus Bowne,What is metabolomics all about? The Future of Molecular Biology, BioTechniques 2009; 46:363-365.

David S Wishart, Metabolomics for Drug Discovery, Development and Monitoring, Business Briefing: Futured Discovery 2006.

Dr Chris W W Beecher and Reid Tripp, Metabolomics – Applications in Drug Discovery and Development, Business Briefing: Pharmatech 2004.

Katja Dettmer, Pavel A. Aronov, and Bruce D. Hammock, Mass spectrometry based-metabolomics, Mass Spectrometry Reviews,2007,26,51-75.

Nicholson JK, Lindon JC. "Systems biology: Metabonomics". Nature 455 (7216): 2008; 1054–6

Richard D. Beger, Jinchun Sun, Laura K. Schnackenberg’ Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity, Toxicology and Applied Pharmacology 243; 2010; 154–166.

George G. Harrigan, Ph.D.; Greg Maguire, Ph.D.; and Laszlo Boros, M.D, Metabolomics in Alcohol Research and Drug Development, Metabolomics, Alcohol Research, and Drug Development. Vol. 31, No. 1, 2008,26-35

Angelo D’Alessandro and Lello Zolla, Metabolomics and cancer drug discovery: let the cells do the talking Drug Discovery Today ; 17(1/2); 2012; 12-21.

Yuntao Dai, Zhenyu Li, Liming Xue, Chunyan Dou, Yuzhi Zhou, Lizeng Zhang, Xuemei Qin ,Metabolomics study on the anti-depression effect of xiaoyaosan on rat model of chronic unpredictable mild stress, Journal of Ethnopharmacology 128; 2010; 482–489.

B. van Ravenzwaay, G. Coelho-Palermo Cunha, E. Leibold ,R. Looser , W. Mellert , A. Prokoudine , T. Walk, J. Wiemer ,The use of metabolomics for the discovery of new biomarkers of effect, Toxicology Letters 172 ;2007; 21–28.

Gregory D. Lewis, MD, Aarti Asnani, BS Robert E. Gerszten, MD,Application of Metabolomicsto Cardiovascular Biomarker and Pathway Discovery, Metabolomics in Biomarker Discovery, JACC; 52(2); 2008; 117-23.

Joanna R. Zgoda-Pols , Swapan Chowdhury , Mark Wirth , Michael V. Milburn,Danny C. Alexander, Kevin B. Alton, Metabolomics analysis reveals elevation of 3- indoxyl sulfate in plasma and brain during chemicallyinduced acute kidney injury in mice: Investigation of nicotinic acid receptor agonists, Toxicology and Applied Pharmacology 255;2011;48–56.

Lloyd W. Sumner, Pedro Mendes, Richard A, Dixon Plant metabolomics: large-scale phytochemistry in the functional genomics era, Phytochemistry 62; 2003; 817–836.

Jan van der Greef, Aram Adourian1, Pieter Muntendam1,Robert N. McBurney Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development Drug Discovery Today: Technologies; 3(2);2006.

Douglas B. Kell,Systems biology, metabolic modeling and metabolomics in drug discovery and development Drug Discovery Today;11(23/24);2006.

Wolfram Weckwerth and Katja, Morgenthal Metabolomics:from pattern recognition to biological interpretation Drug Discovery Today;10(22);2005.

Dunn WB, Bailey NJ, Johnson HE. Measuring the metabolome: current analytical technologies. Analyst 2005; 130: 606–625.

Lindon JC, Holmes E, Bollard ME, Stanley EG, Nicholson JK. Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis, Biomarkers ;2004; 9: 1–31.

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