Formulation and evaluation of Phytosomesyrup for Hepato-protective activity of Clerodendroninfortunatum Linn., root extract

Abstract

The root portions of the Clerodendroninfortunatum Linn. roots extracted with ethanol by cold maceration process. The extract was vacuum dried and subjected to phytochemical screening for the detection of various phyto constituents.Polyphenols in plant extracts react with specific redox reagents (Folin- Ciocalteu reagent) to form a blue complex that can be quantified by visible-light spectrophotometry. Flavonoids are potent antioxidants and have aroused considerable interest recently because of their potential beneficial effects on human health in fighting diseases. The capacity of flavonoids to act as hepatoprotectant depends upon their molecular structure. Preliminary phytochemical screening of Petroleum ether, Ethanol, Ethyl acetate, Water extract of Clerodendroninfortunatum Linn., were done which gives information about active constituents such as carbohydrates, starch, mucilage, saponins, flavanoids, tannins, phenolic compounds in the different extract and was more in Ethanolic and,Ethyl acetate extract. The. The extracts exhibited potent activity against hepatic cells. The study reveals that Clerodendroninfortunatum possess better hepatoprotective activity.