@article{Tiwari_Agrawal_Thakur_Nagendrappa_Thakur_2018, title={Modelling of Anti-HIV-1 Activity of Piperidine-4-carboxamide CCR5 Antagonist: Role of Structural Manipulatio}, volume={7}, url={https://ijrdpl.com/index.php/ijrdpl/article/view/83}, DOI={10.21276/IJRDPL.2278-0238.2018.7(3).3006-3010}, abstractNote={<p>Present study is aimed to understand the role of structural manipulation in modeling of anti-HIV-1 activity of Piperidine-4-Carboxamide CCR5 antagonists. For the purpose a set of 21 Piperidine-4-Carboxamide has been chosen. Study explores the role of various, structural features like size, substitution and steric properties in anti-HIV-1 activity of Piperidine-4-Carboxamide CCR5 antagonists derivatives. Multiple regression method is adopted to understand the role of structural manipulation in modeling the logIC<sub>50</sub>&nbsp;activity. Statistics generated from the study shows that none of the parameter having statistical significant value of r but bi-parametric to tetra-parametric combinations produced the improved regression value.</p>}, number={3}, journal={International Journal of Research and Development in Pharmacy & Life Sciences}, author={Tiwari, A. K. and Agrawal, N. and Thakur, M. and Nagendrappa, G. and Thakur, A.}, year={2018}, month={Jun.}, pages={3006 - 3010} }