Formulation and evaluation of Taste Masked Mouth Dissolving Tablet of Levocetrizine dihydrochloride by using Ion-Exchange Resin

Authors

  • Rosaline Mishra I.T.S. College of Pharmacy, Ghaziabad, India
  • Moumita Barman I.T.S. College of Pharmacy, Ghaziabad, India
  • Monika Singh I.T.S. College of Pharmacy, Ghaziabad, India
  • Snigdha Bhardwaj I.T.S. College of Pharmacy, Ghaziabad, India
  • Prasoon Kumar Saxena I.T.S. College of Pharmacy, Ghaziabad, India
  • Smriti Sahu I.T.S. College of Pharmacy, Ghaziabad, India

DOI:

https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(5).3104-3109

Keywords:

Levocetirizine dihydrochloride, MDT, Allergic Rhinitis, Kyron T-134, Ion Exchange resin

Abstract

ABSTRACT: Levocetirizine dihydrochloride is a third-generation non-sedating anti-histamine drug derived from the second generation anti-histamine cetrizine. It is H1receptorantagonist.Allergic rhinitis is a symptomatic disorder of the nose induced by inflammation mediated by immunoglobulinE (IgE) in the membrane lining the nose after allergen exposure. Thus, formulating Levocetirizine into an orodispersible dosage form would provide fast relief. The Levocetirizine is bitter in taste so the Kyron T-134 (ion exchange resin synthetic which is inert organic polymers consist of hydrocarbon network to which ionizable groups are attached and they have the ability to exchange their labile ions for ions present in the solution with which they are in contact) was used to mask the taste and to formulate Mouth dissolving tablets using drug resin complex. The tablets were evaluated for the drug content, weight variation, water absorption ratio, wetting time, invitro disintegration, hardness, friability, thickness. All the parameters were found to be acceptable in range. The optimized formulation was disintegrated in 25 seconds and complete drug was released from tablet in10 minutes. It has been compared with marketed formulation and the drug release rate was found to be enhanced. Thus, results showed that Levocetirizine dihydrochloride was successfully formulated into Mouth Dissolving Tablets.

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References

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How to cite this article:

Mishra R, Barman M, Singh M, Bhardwaj S, Saxena PK and Sahu S. Formulation and evaluation of Taste Masked Mouth Dissolving Tablet of Levocetrizine dihydrochloride by using Ion-Exchange Resin. Int. J. Res. Dev. Pharm. L. Sci. 2018; 7(5): 3104-3109. doi: 10.13040/IJRDPL.2278-0238.7(5).3104-3109

This Journal is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

Published

2018-10-15

How to Cite

Mishra, R. ., Barman, M. ., Singh, M. ., Bhardwaj, S. ., Saxena, P. K. ., & Sahu, . S. . (2018). Formulation and evaluation of Taste Masked Mouth Dissolving Tablet of Levocetrizine dihydrochloride by using Ion-Exchange Resin. International Journal of Research and Development in Pharmacy & Life Sciences, 7(5), 3104 - 3109. https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(5).3104-3109