Synthesis, characterization, antimicrobial and antitubercular activity of Some Pyrazoline derivatives from Chalcones bearing indane-1,3-dione as nucleus

Authors

  • Siddharth S. Desai Department of Pharmaceutical Chemistry, Rajiv Memorial Education Society’s College of Pharmacy, Gulbarga-585102, India
  • V. Girija Sastry Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhaparnam530003, India
  • Ashok Malpani Department of Pharmaceutical Chemistry, Rajiv Memorial Education Society’s College of Pharmacy, Gulbarga-585102, India
  • Kishore Singh Department of Pharmaceutical Chemistry, Rajiv Memorial Education Society’s College of Pharmacy, Gulbarga-585102, India

DOI:

https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(2).2530-2534

Keywords:

Chalcones, Phenyl pyrazoline, Microplate Alamar Blue Assay, Antimicrobial activity, Antitubercular activity

Abstract

A series of phenyl pyrazoline derivatives have been synthesized from chalcones of indane-1,3-dione. The substituted chalcones have already been synthesized and reported by us. The phenyl pyrazoline derivatives were synthesized by condensation of chalcone of indane-1,3-dione with phenyl hydrazine in basic medium in the presence of ethanol. The newly synthesized compounds (7a-f) have been characterized by IR and 1H-NMR Spectroscopy and TLC. The new compounds have been evaluated for their antibacterial, antifungal and antitubercular activities.

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How to cite this article

Desai SS, Sastry GV, Malpani A and Singh K. Synthesis, characterization, antimicrobial and antitubercular activity of Some Pyrazoline derivatives from Chalcones bearing indane-1,3-dione as nucleus. Int. J. Res. Dev. Pharm. L. Sci. 2017; 6(2): 2530-2534.doi: 10.13040/IJRDPL.2278-0238.6(2).2530-2534.

This Journal is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

Published

2017-03-15

How to Cite

Desai, S. S. ., Sastry, V. G. ., Malpani, A. ., & Singh, K. . (2017). Synthesis, characterization, antimicrobial and antitubercular activity of Some Pyrazoline derivatives from Chalcones bearing indane-1,3-dione as nucleus. International Journal of Research and Development in Pharmacy & Life Sciences, 6(2), 2530-2534. https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(2).2530-2534