A Comprehensive Review on Buccal DrugDelivery System
DOI:
https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(3).2606-2618Keywords:
Buccal drug delivery, Mucoadhesion, Polymers for buccal drug deliveryAbstract
Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity. The objective of this article is to review buccal drug delivery by discussing the structure and environment of the oral mucosa and highlighting the mechanisms of drug permeation and methodology in evaluating buccal formulations. This review also highlights a brief description of advantages, limitations of buccal drug delivery and theories involved in mucoadhesion along with method of preparation mucoadhesive system, mucoadhesive polymer, and classification of buccal system.
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Giradkar KP, et al, Design development and in vitro evaluation of bioadhesive dosage form for buccal route, International journal of Pharma Research &Development, 2010; 2.
Shidhaye SS, et al, Mucoadhesive bilayered patches for administration of sumatriptan, AAPS pharm Cci Tech, 2009; 9(3).[View in PubMed]
Khanna R, Agarwal SP, Ahuja A. Ind J Pharm Sci, 1997; 59: 299-305.
Ebert CD, Heiber SJ, Dave SC, Kim SW, Mix D. J Control Release, 1994; 28: 37-44.
Cheng L, Padmanabh PB, Thomas PJ. Pharm. Dev Tech, 1997; 2: 265-74.
Mamatha Y, Prasanth VV, Selvi AK, Sipai A. Yadav MV. Review Article on Buccal Drug Delivery A Technical Approach. Journal of Drug Delivery & Therapeutics. 2012; 2(2).
Rathod S, Surve GD, Phansekar M, Bhagwan A. Review on Mouth Dissolving Film Technology. International Journal for Pharmaceutical Research Scholars (IJPRS). 2014; 3(1):635-47.
Semalty M., Semalty A., Kumar G., Indian. J. Pharm. Sci, 2008; 70: 43-48. [View in PubMed]
Nagai T, Konishi R., J. Control Release., 1987; 6: 353-360.
Patel RS, and Poddar SS. Development and characterization of mucoadhesive buccal patches of salbutamol sulphate, Curr. Drug Deliv., 2009; 6: 140-144.
Kumar V, Aggarwal G, Zakir F, Choudhary A. Buccal Bioadhesive Drug Delivery- A Novel Technique: International journal of Pharmacy and Biological sciences. 2011; 1(3):89-102.
Jain NK. Controlled and Novel Drug Delivery. 1st ed. India: CBS Publishers and Distributors; 2004.
Alexander A, Ajazuddin S, TripathiDK, Verma T, Maurya J, Patel S. Mechanism responsible for mucoadhesion of mucoadhesive drug delivery system: a review. Int J App Bio and Pharm Tech. 2011; 2(1):434-45.
Madhav NVS, Ojha A, Tyagi Y, Negi M. Mucoadhesion: a novelistic platform for drug delivery system. Int J Pharm. 2014; 2(9):246-58.
Patel AR, Patel DA, Chaudhry SV. Mucoadhesive buccal drug delivery system. Int J of Pharm and Life Sci. 2011; 2(6):848-56.
Kumar TP, Desai KG and Kumar SG. Mechanism of buccal permeation enhancers, Indian J. Pharm. Edu., 2002; 36(3): 147-151.
Edgar W.M., Saliva: its secretion, composition and functions, Br.Dent. J, 1992; 172:305-312.
N.G. Raghavendra Rao et al;" Overview of buccal drug delivery system "; J. Pharm. Sci. & Res.2013;5(4): 80 – 88.
Satinder Kakar, Ramandeep Singh, Alok Semwal. Transdermal drug delivery as a boon. Asian Pacific Journal of Health Sciences, 2014; 1(1): 13-25.
AC Williams, BW Barry. Penetration enhancers. Adv. Drug Del. Rev., 2004; 56: 603-618. [View in PubMed]
Remminghorst and Rehm, Microbial Production of Alginate: Biosynthesis and Applications. Caister Academic Press. Microbial Production of Biopolymers and Polymer Precursors. 2009; 1(2):9.
Kumar TP, Desai KG and Kumar SG. Mechanism of buccal permeation enhancers, Indian J. Pharm. Edu., 2002; 36(3):147-15.
Tomolin, J., Taylor J.S., and Read N.W., The effect of mixed faecal bacteria on selection of viscous polysaccharide in vitro, Nutr. Rep. Int., 1989; 3(9):121–13.
Macfarlane G.T., Hay S., Macfarlane S., and Gibson G.R., Effect of different carbohydrates on growth polysaccharidases and glycosidase production of bacteroidesovatus in batch and continuous culture, J. Appl. Bacteriol., 1990; 68:179-187.
Shahidi F., and Synowiecki J., Isolation and characterization of nutrients and value-added products from snow crab (chionoecetesopilio) and shrimp (Pandalus borealis) processing discards, J. Agri. and Food Chemi., 1991;39 (8):1527–1532.
Shojaei Amir H, Buccal Mucosa as A Route for Systemic Drug Delivery: A Review; J Pharm Pharmaceut Sci (www.ualberta.ca/~csps) 1998;1 (1):15-30. [View in PubMed]
Sevda Senel, Mary Kremer, Katalin Nagy and Christopher Squier, Delivery of Bioactive Peptides and Proteins Across Oral (Buccal) Mucosa, Current Pharmaceutical Biotechnology, 2001; 2: 175-186.
Shojaei AH. Buccal mucosa as a route for systemic drug delivery: a review. J Pharm Pharmaceut Sci. 1998;1: 15-30. [View in PubMed]
Gandhi RB, Robinson JR. Oral cavity as a site for bioadhesive drug delivery. Adv Drug Deliv Rev. 1994; 13:43-74.
Salamat-Miller N, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery, Adv. Drug Deliv. Rev. 2005; 57:1666-91. [View in PubMed]
Dowty ME, Knuth KE, Irons BK, Robinson JR. Transport of thyrotropin releasing hormone in rabbit buccal mucosa in vitro. Pharm Res. 1992;9: 1113-22.
Smart JD. Lectin-mediated drug delivery in the oral cavity. Adv Drug Deliv Rev. 2004; 56:481-9. [View in PubMed]
Collins LMC, Dawes C. The surface area of adult human mouth and thickness of salivary film covering the teeth and oral mucosa. J Dent Res. 1987; 66:1300-2. [View in PubMed]
Amir H, et al, Systemic drug delivery via the buccal mucosal route, Pharmaceutical technology, 2001; 4: 1-27.
Thuslasiramaraju TV, Tejeswar Kumar B, Kartik Kumar A, Naresh T. Bucco Adhesive Drug Delivery System: A Novel Drug Delivery Technique. www.ajrbps.com.
Pramodkumar TM et al, Oral transmucosal drug delivery systems, Indian drug, 2004; 41(2): 63-1.
Edsman K, et al, Pharmaceutical applications of mucoadhesion for the non-oral routes, Journal of pharmacy & pharmacology, 2005; 57: 3-19.
Steward A et al, The Effect of Enhancers on the Buccal Absorption of Hybrid (BDBB) Alpha Interferon, Int. J. Pharm, 1994; 104:145–149.
Aungst BJ and Rogers NJ, Site Dependence of Absorption- Promoting Actions of Laureth9, Na Salicylate, Na2EDTA, and Aprotinin on Rectal, Nasal, and Buccal Insulin Delivery, Pharm. Res,1988; 5 (5): 305–308.
RaghavendraRao NG, Shravani B, Reddy MS. Overview on Buccal Drug Delivery System. Journal of pharmaceutical sciences and research. www.jpsr.pharmainfo.in
Nazila SM, Montakarn C, Thomas PJ. The use of mucoadhesive polymers in buccal drug delivery. Advanced Drug Delivery Reviews. 2005; 57:1666–91. [View in PubMed]
Boddupalli BM, Mohammad ZNK, Nath RA, Banji D. Mucoadhesive drug delivery system an overview. J Adv Pharm Tech Res. 2010;1(4):381-7. [View in PubMed]
Gandhi SD, Priyanka RP, Rahul U, Tambawala T, Shah MA. Mucoadhesive drug delivery systems-An unusual maneuver for specific drug delivery system. Int J Pharm Sci. 2011; 851-871.
SatheeshMadhav NV, Ashok KS, Pragati S, Kuldeep S. Orotransmucosal drug delivery systems: A review. Journal of Controlled Release. 2009; 140:2–11. [View in PubMed]
Pharmaceutics the science of dosage form Design 2nd edition edited by M. E. Aulton. Published by Harcourt publishers Limited. 2002; 198-200.
Jain NK. Controlled and Novel Drug Delivery, 1st edition, published by CBS Publishers and Distributors, New Delhi. 1997; 52-81.
Gandhi SD, Priyanka RP, Rahul U, Tambawala T, Shah MA. Mucoadhesive drug delivery systems-An unusual maneuver for site specific drug delivery system. An Int. J.Pharm. Sci. ISSN: 0976- 7908: 851-871.
Asija R, Kumawat JK, Sharma D. Mucoadhesive drug delivery system: a review. J of Drug Dis and Therapeutics. 2013; 12(1): 1-8.
Smart JD. The basics and underlying mechanisms of mucoadhesion. Adv Drug Del Rev, 2005;57:1556-1568. [View in PubMed]
Butorphanol Administered Intravenously and via a Buccal Patch, A Thesis Submitted to the office of Graduate Studies of Texas A&M University in Partial Fulfillment of the requirements for the Degree of Master of Science, May 2003.
Wise Donald L, Handbook of Pharmaceutical controlled release technology: 255-265.
Yajaman S., Bandyopadhyay A.K., Buccal bioadhesive drug delivery- A promising option for orally less efficient drugs, Journal of Controlled Release, 2006;114:15–40. [View in PubMed]
Jain N.K., Controlled and novel drug delivery; 65-75; 371-377.
Indian Journal of Pharmaceutical Science, July-Aug. 2004; 66 (4): 371-536:556-562.
www.controlled drugdelivery.com
Patel VM, Prajapati BG, Patel MM. Design and characterization of chitosan-containing mucoadhesive buccal patches of propranolol hydrochloride, Acta Pharm, 2007; 57: 61-72. [View in PubMed]
Yong CS, Jung JH, Rhee JD, Kim CK, Choi H.G. Physiochemical characterization and evaluation of buccal adhesive tablets containing omeprazole. Drug Dev Ind Pharm, 2001; 27(5): 447-455.
Kamel AH et al. Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases, AAPS Pharm Sci Tech, 2007; 8(3): 75.
Pramodkumar TM et al. Oral transmucosal drug delivery systems, Indian Drug, 2004; 41(2): 63-12.
Repka MA, Repka SL, McGinity JM. Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation. US J Control Release, 2002; 2:47–57.
Anujkumar, VikasP, Naveen P, KumudPadhee, MinakshiG, Neeta S, Formulation development & evaluation of carvedilol bioerodible buccal mucoadhesive patches. Pharmacie Globale, Int J Comprehensive Pharm 2011; 3(7):1-5.
Miller NS, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery, Advanced Drug Delivery Reviews 2005; 57:1666–91. [View in PubMed]
Vishnu MP, Bhupendra GP, Madhabhai MP. Design and in vitro characterization of eudragit containing mucoadhesive buccal patches. Int J PharmTech Res, 2009; 1(3):783-9.
Ching HS. Bioadhesive polymers as platforms for oral controlled drug delivery II: Synthesis and evaluation of some swelling, water- insoluble bioadhesive polymers. J Pharm Sci 1985; 74(4):399– 405.
Coutel EA, Maitani Y, Veillard M, Machida Y, Nagai T. Combined effects of pH, cosolvent and penetration enhancers on the in vitro buccal absorption of propranolol through excised hamster cheek pouch. Int J Pharm, 1992; 84:117-28.
Apoorva M, Neha C, Geeta A. Formulation and characterization of fast dissolving buccal films: A review. Der Pharmacia Lettre 2011; 3(1):152-65.
Siegel IA, Gordon HP. Surfactant-induced increase of permeability of rat oral mucosa to non-electrolytes in vivo. Arch Oral Biol,1985; 30:43-7. [View in PubMed]
Leung SS, Robinson JR. Polymer structure features contributing to mucoadhesion: II. J ContrRel 1990; 12:187–94.
Bottenberg P, Cleymaet R, Muynek CD, Remon JP, Coomans D, Slop D. Development and testing of bioadhesive, floride-containg slow-release tablets for oral use. J PharmPharmacol 1991; 43:457-64. [View in PubMed]
AmitKhairnar, Parridhi J, Dheeraj B, Dinesh J. Development of mucoadhesive buccal patch containing Patel R, Shardul N, Patel J, Baria A. overview on buccal mucoadhesive films. Arch Pharm Sci& Res 2009; 1(2):212-7.
Aceclofenac: in vitro evaluations. Int J PharmTech Res 2009; 1(4):978-81.
Chandra SK, Ramesh G, Vamshi VY, KishanV, Madhsudanrao Y. Development of mucoadhesive patches for buccal administration of prochlorperazine: Evaluation of in vitro release and mechanical properties: Int J Pharma Sci and Nanotech, 2008;1(1): 64-70.
Peppas NA, Buri PA. Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues. J ContrRel 1985; 2:257–75.
Harshad GP, Janak JJ, Tarun KP,Vishnu MP. Buccal patch: A technical note. Int J PhamSci Rev Res 2010; 4(3):178-82.
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