Formulation and evaluation pf Phospholipid complex of Green Tea Polyphenol


  • Pranjal Ray Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati, India
  • Bhupen Kalita Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati, India



Green tea, phytosomes, anti-solvent evaporation, bioavailability, solubility


OBJECTIVE: Phospholipid complexes are formulated to improve absorption, bioavailability and stability of herbal product. There are many herbal extracts having excellent in-vitro activity but less in-vivo activity because of their macromolecular size and poor aqueous/lipid solubility, which result in poor absorption and bioavailability. Green tea polyphenol has poor oral bioavailability due to many known and unknown reasons and is unstable in the gastrointestinal tract. There have been published reports that encapsulating green tea polyphenols in drug delivery carrier significantly delayed its degradation in simulated digestive fluids and leads to improved oral bioavailability.

METHODS: The present work aims in improving the GI dissolution and oral bioavailability of green tea extract rich in Epigallocatechin-3-gallate (EGCG) by formulating into phospholipid complex. EGCG-Phospholipid complex (EPC) was formulated by anti-solvent evaporation method using green tea extract and phosphatidylcholine (PC) in the ratio of 0.5:1, 0.75:1, 1:1, 1:0.75 and 1:0.5.

RESULT: EPC were characterized by solubility, particle size, drug content, % entrapment efficacy, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and in vitro dissolution study. The results showed that the average particle size of optimized EPC formulation was 201.96 nm. The Drug content and Entrapment efficiency was found to be 90.57 ± 1.187 and 95.41 ± 0.898, respectively. In vitro drug release studies revealed that the cumulative % drug release of the optimized EPC was 98.41% at 3 hours.

CONCLUSION: Results of the physicochemical and drug release studies suggested that EPC would serve as useful novel drug delivery system and provide improved oral bioavailability.


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How to cite this article:

Ray P and Kalita B. Formulation and evaluation pf Phospholipid complex of Green Tea Polyphenol. Int. J. Res. Dev. Pharm. L. Sci. 2017; 6(6): 2813-2819. Doi: 10.13040/IJRDPL.2278-0238.6(6). 2813-2819.

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How to Cite

Ray, P. ., & Kalita, B. . (2017). Formulation and evaluation pf Phospholipid complex of Green Tea Polyphenol. International Journal of Research and Development in Pharmacy & Life Sciences, 6(6), 2813 - 2819.