Phytochemical analysis, exploration of antidiabetic and antioxidant potential of Anthocephalus cadamba (Roxb.)
Keywords:Antidiabetic, Antioxidant, methanolic extract, cadambine, Anthocephalus cadamba
The most common disease nowadays is diabetes. In a fast-changing world, many means to treat diabetes naturally are explored by experts and clinicians today. Continuing use of insulin and other oral hypoglycemic agent creates undesirable side-effects, consequentially, unrestrained increase in blood sugar as well as complications associated with heart diseases; diabetics may have to face. To evade such glitches, herbal medications has superior advantages. As an alternative of using allopathic formulations, it is thus, gainful to use ayurvedic preparations for healthier regulation of diabetes mellitus. Current research was thus taken on to explore the anti-diabetic and antioxidant activities of crude extracts and pure compound obtained from the bark of Anthocephalus cadamba. The methanolic extract exhibited promising antidiabetic and antioxidant activity. Grounded on these results, the methanolic extract was fractionated on a silica gel column chromatography in a bioassay-led fractionation resulting in one known isolate, cadambine showing potent anti-diabetic activity, more than that of the positive control, glibenclamide. The results indicated that Anthocephalus cadamba methanolic extract (ACME) and the isolated compound (Cadambine) are potential natural agents to control diabetes. Alloxan significantly induced hyperglycemia; Oral administration of test samples for 14 days caused a significant decrease in blood glucose levels. The possible mechanism by which ACME mediated its antidiabetic effect could be by potentiation of pancreatic secretion of insulin from existing β-cells of islets in the extract treated animals.
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How to cite this article:
Singh HP, Irchhaiya R, Verma A, Pandey H and Singh PP. Phytochemical analysis, exploration of antidiabetic and antioxidant potential of Anthocephalus cadamba (Roxb.). Int. J. Res. Dev. Pharm. L. Sci. 2017; 6(6): 2800-2805. Doi: 10.13040/IJRDPL.2278-0238.6(6). 2800-2805.
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