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Abstract


IJRDPL - Vol 5, issue 6 (2016), October - Noember

Pages: 2410-2413

PHARMACOLOGICAL INVESTIGATION OF LEAVES OF ANTHOCEPHALUS CADAMBA (ROXB) FOR HEPATOPROTECTIVE ACTIVITY

Author: Ramji Swarnkar*1, S.K. Jain2, Pankaj Singh Niranjan1, Suneel Kumar Niranjan1

Category: Life Sciences

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Abstract:

The objective of the present investigation was to study hepatoprotective activity of ethanolic extract of leaves of Anthocephalus cadamba, paracetamol induced liver damage model in rats. In this study, liver damage in rats done by paracetamol(2g/kg b.w.) in Tween 80. The ethanolic extract of the plant was administered in rats daily for seven days. The biochemical parameters were investigated. Histopathological changes in liver were studied. Silymarine was used as a standard hepatoprotective agents. The result indicates that biochemical changes produced by paracetamol were restored to normal by ethanolic extract. The ethanolic extract of leaves of Anthocephalus cadamba (ROXB.) showed significant hepatoprotective effect againest paracetamol induced liver damage model in rats.

Keywords: Anthocephalus cadamba, hepatoprotective, Silymarine, Paracetamol