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IJRDPL - Vol 6, issue 2 (2017), February- March

Pages: 2535-2547

Design and evaluation of a Sustained Release Gastroretentive Dosage form of Captopril

Author: Hakim Singh Rajput*, Mithun Bhowmick, Vaishali Rathi and Jagdish Rathi


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Abstract: Sustained drug delivery means not only prolonged duration of drug delivery but also implies predictability and reproducibility of drug release kinetics. In the present study gastroretentive dosage form (tablet) was selected as a method to design sustained release dosage forms because it is a rapidly expanding technology. The objective of the work was to design sustained release tablets of Captopril as gastroretentive drug delivery dosage form of a drug meant for management of treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by diabetes, and to improve survival after a heart attack. Formulation of gastroretentive drug delivery dosage forms are done based on optimization under factorial design of formula and classed formulation batches in which concentration of polymer HPMC of various grades (HPMC K15 M, HPMC K100M and HPMC K4M) varied with the ration of sodium bi carbonate and microcrystalline cellulose. Therefore, the Aim of the present work is design to formulate and evaluate gastroretentive dosage form (tablets) of Captopril for efficient sustained release after oral administration in case of congestive heart failure, kidney problems caused by diabetes.

Keywords: Sustained drug delivery system, Tablet, Captopril, HPMC, Gastro-intestinal tract, Bioavailability

DOI: 10.21276/IJRDPL